The porcine TTR locus maps to chromosome 6q

A L Archibald, S Couperwhite, Z H Jiang

Research output: Contribution to journalArticlepeer-review

Abstract

The sequence of a cDNA clone encoding porcine transthyretin (prealbumin) was used to develop polymorphic markers for the TTR locus. The single-strand conformation polymorphism (SSCP) detected is caused by a silent A/T mutation in the penultimate coding codon and can also be revealed as a SacI restriction fragment length polymorphism (RFLP). The TTR locus was mapped to chromosome 6q by segregation and linkage analysis with these polymorphisms. This assignment confirms the predictions of homology between human chromosome 18 and pig chromosome 6q2.5-q2.6.
Original languageEnglish
Pages (from-to)351-3
Number of pages3
JournalAnimal Genetics
Volume27
Issue number5
Publication statusPublished - Oct 1996

Keywords

  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 18
  • Cloning, Molecular
  • DNA Primers
  • Deoxyribonucleases, Type II Site-Specific
  • Female
  • Genetic Linkage
  • Humans
  • Male
  • Mice
  • Molecular Sequence Data
  • Pedigree
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Prealbumin
  • Rats
  • Sheep
  • Swine

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