The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area

Claire Monteiller; Lang Tran; William MacNee; Steve Faux; Alan Jones; Brian Miller; Ken Donaldson

doi:10.1136/oem.2005.024802

The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area

Claire Monteiller, Lang Tran, William MacNee, Steve Faux, Alan Jones, Brian Miller, Ken Donaldson

Research output: Contribution to journal › Article › peer-review

Abstract

Rats exposed to high airborne mass concentrations of low-solubility low-toxicity particles (LSLTP) have been reported to develop lung disease such as fibrosis and lung cancer. These particles are regulated on a mass basis in occupational settings, but mass might not be the appropriate metric as animal studies have shown that nanoparticles (ultrafine particles) produce a stronger adverse effect than fine particles when delivered on an equal mass basis.

Original language	English
Pages (from-to)	609-15
Number of pages	7
Journal	Occupational and Environmental Medicine
Volume	64
Issue number	9
DOIs	https://doi.org/10.1136/oem.2005.024802
Publication status	Published - Sept 2007

Keywords / Materials (for Non-textual outputs)

Cells, Cultured
Dose-Response Relationship, Drug
Epithelial Cells
Glutathione
Humans
Inhalation Exposure
Interleukin-8
Lung Neoplasms
Nanoparticles
Oxidative Stress
Particle Size
Particulate Matter
Pulmonary Fibrosis
Quartz
RNA, Messenger
Respiratory Mucosa
Titanium

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10.1136/oem.2005.024802

The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro the role of surface area.
Copyright © 2007 BMJ Publishing Group
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http://oem.bmj.com/content/64/9/609

Cite this

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title = "The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area",

abstract = "Rats exposed to high airborne mass concentrations of low-solubility low-toxicity particles (LSLTP) have been reported to develop lung disease such as fibrosis and lung cancer. These particles are regulated on a mass basis in occupational settings, but mass might not be the appropriate metric as animal studies have shown that nanoparticles (ultrafine particles) produce a stronger adverse effect than fine particles when delivered on an equal mass basis.",

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author = "Claire Monteiller and Lang Tran and William MacNee and Steve Faux and Alan Jones and Brian Miller and Ken Donaldson",

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volume = "64",

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T1 - The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro

T2 - the role of surface area

AU - Monteiller, Claire

AU - Tran, Lang

AU - MacNee, William

AU - Faux, Steve

AU - Jones, Alan

AU - Miller, Brian

AU - Donaldson, Ken

PY - 2007/9

Y1 - 2007/9

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AB - Rats exposed to high airborne mass concentrations of low-solubility low-toxicity particles (LSLTP) have been reported to develop lung disease such as fibrosis and lung cancer. These particles are regulated on a mass basis in occupational settings, but mass might not be the appropriate metric as animal studies have shown that nanoparticles (ultrafine particles) produce a stronger adverse effect than fine particles when delivered on an equal mass basis.

KW - Cells, Cultured

KW - Dose-Response Relationship, Drug

KW - Epithelial Cells

KW - Glutathione

KW - Humans

KW - Inhalation Exposure

KW - Interleukin-8

KW - Lung Neoplasms

KW - Nanoparticles

KW - Oxidative Stress

KW - Particle Size

KW - Particulate Matter

KW - Pulmonary Fibrosis

KW - Quartz

KW - RNA, Messenger

KW - Respiratory Mucosa

KW - Titanium

U2 - 10.1136/oem.2005.024802

DO - 10.1136/oem.2005.024802

M3 - Article

C2 - 17409182

SN - 1351-0711

VL - 64

SP - 609

EP - 615

JO - Occupational and Environmental Medicine

JF - Occupational and Environmental Medicine

IS - 9

ER -

The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area

Abstract

Keywords / Materials (for Non-textual outputs)

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