The prognostic influence of bcl-2 in malignant glioma

F E McDonald, J W Ironside, A Gregor, B Wyatt, M Stewart, R Rye, J Adams, H W W Potts

Research output: Contribution to journalArticlepeer-review

Abstract

The bcl-2 gene is one of a complex group of genes which control programmed cell death. Bcl-2 acts to extend cell survival by blocking apoptosis, and thereby may influence tumour prognosis. This study of 187 high grade gliomas reviews clinicopathological prognostic features and the relationship to bcl-2 expression. Bcl-2 immunostaining was assessed in 159 specimens from these patients, by scoring systems of 0 to 3 for intensity of scoring and proportion of cells staining. Age, histology, pre- and post-operative performance status were found to be strongly predictive of survival (log rank test P<0.0001). The type of surgery performed did not influence survival in this group of patients. The expression of bcl-2 had a significant relationship with survival (univariate Cox model P=0.0302, hazard ratio 0.8, 95% confidence interval 0.65-0.98), with increased staining associated with improved survival. Multivariate analysis showed performance status, histology and proportion of cells staining for bcl-2 to be independently predictive of survival. Bcl-2 staining was not related to histological grade of tumours.

Original languageEnglish
Pages (from-to)1899-904
Number of pages6
JournalBritish Journal of Cancer
Volume86
Issue number12
DOIs
Publication statusPublished - 17 Jun 2002

Keywords

  • Adolescent
  • Adult
  • Aged
  • Biopsy
  • Brain Neoplasms
  • Child
  • Female
  • Follow-Up Studies
  • Glioma
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Middle Aged
  • Prognosis
  • Proto-Oncogene Proteins c-bcl-2
  • Survival Rate

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