The prognostic value of microalbuminuria in puppies with canine parvoviral enteritis

Ioannis Oikonomidis, N Soubasis, Jose Joaquin Ceron, K Theodorou, Timoleon Rallis, Z Polizopoulou

Research output: Contribution to journalArticlepeer-review

Abstract

Increased urine albumin concentration (UALB) or urine albumin-to-creatinine ratio (UACR) at admission has been associated with systemic disease and increased morbidity and mortality in critically ill canine patients. The objective of this study was to assess the prognostic value of UALB and UACR for the survival, as well as for the development and duration of systemic infl ammatory response syndrome (SIRS) in puppies with canine parvoviral enteritis (CPVE). Unvaccinated puppies, aged 1-12 months with confi rmed CPVE, hospitalized for ≥5 days were included. Urine was collected at admission via cystocentesis; albumin was measured immunoturbidimetrically and creatinine spectrophotometrically. The presence of SIRS was daily evaluated. Statistical analysis was conducted using R language. Twenty-six dogs were enrolled; 12/26 (46%) developed SIRS during hospitalization, while 5/26 (19%) died. A signifi cant correlation was found between UALB and UACR (ρ=0.868, p<0.001). The dogs with SIRS had higher median UALB [0.5 (0-12.7) mg/dL] and UACR [4.2 (0-2,093) mg/g] compared to dogs without SIRS [UALB= 0.1 (0-0.8) mg/dL, UACR= 1.6 (0-5.6) mg/g], but the differences were non-signifi cant (p>0.05). SIRS duration was signifi cantly correlated with UACR (ρ=0.427, p=0.030), but not with UALB (ρ=0.386, p=0.052). The nonsurvivors had higher median UALB [0.6 (0.1-12.7) mg/dL] and UACR [19.6 (0.7-2,093) mg/g] compared to survivors [UALB= 0.2 (0-1.5) mg/dL, UACR= 2.3 (0-16.9) mg/g], but the differences were non-signifi cant (p>0.05). UACR appears to be a prognostic indicator of SIRS duration in puppies with CPVE. However, a large-scale study is warranted to confi rm the usefulness of UALB and UACR for clinical risk assessment in puppies with CPVE.
Original languageEnglish
JournalActa Veterinaria
Early online date29 Mar 2019
DOIs
Publication statusE-pub ahead of print - 29 Mar 2019

Keywords

  • dog
  • inflammation
  • SIRS
  • systemic inflammatory response syndrome
  • urine albumin
  • urine creatinine

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