The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease

Sofia A Oliveira, Eden R Martin, William K. Scott, Kristin K Nicodemus, Gary W. Small, Donald E Schmechel, P Murali Doraiswamy, Allen D Roses, Ann M Saunders, John R Gilbert, Jonathan L Haines, Jeffery M. Vance, Margaret A Pericak-Vance

Research output: Contribution to journalArticlepeer-review

Abstract

Previous studies have reported conflicting results regarding the association of the Q7R polymorphism in the Saitohin gene with late-onset Alzheimer disease (AD). Given that AD is a tauopathy but no mutations or polymorphisms in Tau have been consistently associated with AD, and that Saitohin is nested in intron 9 of Tau and shares a similar expression pattern, we tested this association in 690 multiplex AD families and in a case-control sample (903 patients and 320 controls). We found no evidence of significant association of this polymorphism with risk of AD using family-based and case-control tests of association.

Original languageEnglish
Pages (from-to)143-6
Number of pages4
JournalNeuroscience Letters
Volume347
Issue number3
Publication statusPublished - 28 Aug 2003

Keywords

  • Alzheimer Disease
  • Case-Control Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Polymorphism, Genetic
  • tau Proteins
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

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