The "quasi-stable" lipid shelled microbubble in response to consecutive ultrasound pulses

D. H. Thomas, M. Butler, T. Anderson, M. Emmer, H. Vos, M. Borden, E. Stride, N. de Jong, V. Sboros

Research output: Contribution to journalArticlepeer-review

Abstract

Controlled microbubble stability upon exposure to consecutive ultrasound exposures is important for increased sensitivity in contrast enhanced ultrasound diagnostics and manipulation for localised drug release. An ultra high-speed camera operating at 13 × 106 frames per second is used to show that a physical instability in the encapsulating lipid shell can be promoted by ultrasound, causing loss of shell material that depends on the characteristics of the microbubble motion. This leads to well characterized disruption, and microbubbles follow an irreversible trajectory through the resonance peak, causing the evolution of specific microbubble spectral signatures.
Original languageEnglish
Article number071601
Number of pages4
JournalApplied Physics Letters
Volume101
Issue number7
DOIs
Publication statusPublished - 13 Aug 2012

Keywords

  • WALL
  • BUBBLES
  • BEHAVIOR
  • CONTRAST AGENT DESTRUCTION

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