Abstract
Activation of the platelet integrin alpha 2 beta 1 is closely regulated due to the high thrombogenicity of its ligand. As a beta 1 interacting kinase, ILK represents a candidate intracellular regulator of alpha 2 beta 1 in human platelets.
Original language | English |
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Pages (from-to) | 1443-52 |
Number of pages | 10 |
Journal | Journal of Thrombosis and Haemostasis |
Volume | 2 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2004 |
Keywords / Materials (for Non-textual outputs)
- Androstadienes
- Blood Platelets
- Cell Adhesion
- Cell Line
- Collagen
- Enzyme Activation
- Enzyme Inhibitors
- Flow Cytometry
- Gene Expression Regulation, Enzymologic
- Humans
- Immunoprecipitation
- Integrin alpha2beta1
- Megakaryocytes
- Phosphatidylinositol 3-Kinases
- Phosphorylation
- Platelet Activation
- Platelet Aggregation
- Protein Binding
- Protein Kinase C
- Protein-Serine-Threonine Kinases
- Thrombin
- Time Factors
- Transfection