The regulation of integrin-linked kinase in human platelets: evidence for involvement in the regulation of integrin alpha 2 beta 1

J M Stevens, P A Jordan, T Sage, J M Gibbins

Research output: Contribution to journalArticlepeer-review

Abstract

Activation of the platelet integrin alpha 2 beta 1 is closely regulated due to the high thrombogenicity of its ligand. As a beta 1 interacting kinase, ILK represents a candidate intracellular regulator of alpha 2 beta 1 in human platelets.
Original languageEnglish
Pages (from-to)1443-52
Number of pages10
JournalJournal of Thrombosis and Haemostasis
Volume2
Issue number8
DOIs
Publication statusPublished - Aug 2004

Keywords

  • Androstadienes
  • Blood Platelets
  • Cell Adhesion
  • Cell Line
  • Collagen
  • Enzyme Activation
  • Enzyme Inhibitors
  • Flow Cytometry
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Immunoprecipitation
  • Integrin alpha2beta1
  • Megakaryocytes
  • Phosphatidylinositol 3-Kinases
  • Phosphorylation
  • Platelet Activation
  • Platelet Aggregation
  • Protein Binding
  • Protein Kinase C
  • Protein-Serine-Threonine Kinases
  • Thrombin
  • Time Factors
  • Transfection

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