The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS)

N Hirani; F Antonicelli; R M Strieter; M S Wiesener; P J Ratcliffe; C Haslett; S C Donnelly

The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS)

N Hirani, F Antonicelli, R M Strieter, M S Wiesener, P J Ratcliffe, C Haslett, S C Donnelly

Research output: Contribution to journal › Article › peer-review

Abstract

The acute respiratory distress syndrome (ARDS) represents a form of severe acute inflammatory lung disease. We have previously demonstrated significantly raised interleukin-8 (IL-8) levels in the lungs of at-risk patients that progress to ARDS, and identified the alveolar macrophage as an important source of this chemokine. We wished to extend this study in a well-defined group of patients with major trauma, and to investigate potential mechanisms for rapid intrapulmonary IL-8 generation.

Original language	English
Pages (from-to)	685-97
Number of pages	13
Journal	Molecular Medicine
Volume	7
Issue number	10
Publication status	Published - 2001

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The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS).
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http://molmed.org/journal/articles/17/572

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title = "The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS)",

abstract = "The acute respiratory distress syndrome (ARDS) represents a form of severe acute inflammatory lung disease. We have previously demonstrated significantly raised interleukin-8 (IL-8) levels in the lungs of at-risk patients that progress to ARDS, and identified the alveolar macrophage as an important source of this chemokine. We wished to extend this study in a well-defined group of patients with major trauma, and to investigate potential mechanisms for rapid intrapulmonary IL-8 generation.",

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The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS). / Hirani, N; Antonicelli, F; Strieter, R M; Wiesener, M S; Ratcliffe, P J; Haslett, C; Donnelly, S C.

In: Molecular Medicine, Vol. 7, No. 10, 2001, p. 685-97.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS)

AU - Hirani, N

AU - Antonicelli, F

AU - Strieter, R M

AU - Wiesener, M S

AU - Ratcliffe, P J

AU - Haslett, C

AU - Donnelly, S C

N1 - DOI not available

PY - 2001

Y1 - 2001

N2 - The acute respiratory distress syndrome (ARDS) represents a form of severe acute inflammatory lung disease. We have previously demonstrated significantly raised interleukin-8 (IL-8) levels in the lungs of at-risk patients that progress to ARDS, and identified the alveolar macrophage as an important source of this chemokine. We wished to extend this study in a well-defined group of patients with major trauma, and to investigate potential mechanisms for rapid intrapulmonary IL-8 generation.

AB - The acute respiratory distress syndrome (ARDS) represents a form of severe acute inflammatory lung disease. We have previously demonstrated significantly raised interleukin-8 (IL-8) levels in the lungs of at-risk patients that progress to ARDS, and identified the alveolar macrophage as an important source of this chemokine. We wished to extend this study in a well-defined group of patients with major trauma, and to investigate potential mechanisms for rapid intrapulmonary IL-8 generation.

M3 - Article

C2 - 11713368

VL - 7

SP - 685

EP - 697

JO - Molecular Medicine

JF - Molecular Medicine

SN - 1076-1551

IS - 10

ER -

The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS)

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