The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS)

N Hirani, F Antonicelli, R M Strieter, M S Wiesener, P J Ratcliffe, C Haslett, S C Donnelly

Research output: Contribution to journalArticlepeer-review

Abstract

The acute respiratory distress syndrome (ARDS) represents a form of severe acute inflammatory lung disease. We have previously demonstrated significantly raised interleukin-8 (IL-8) levels in the lungs of at-risk patients that progress to ARDS, and identified the alveolar macrophage as an important source of this chemokine. We wished to extend this study in a well-defined group of patients with major trauma, and to investigate potential mechanisms for rapid intrapulmonary IL-8 generation.
Original languageEnglish
Pages (from-to)685-97
Number of pages13
JournalMolecular Medicine
Volume7
Issue number10
Publication statusPublished - 2001

Fingerprint

Dive into the research topics of 'The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS)'. Together they form a unique fingerprint.

Cite this