Abstract / Description of output
The activity of the transcription factor paired box gene 5 (Pax5) is essential for many aspects of B lymphopoiesis including the initial commitment to the lineage, immunoglobulin rearrangement, pre-B cell receptor signalling and maintaining cell identity in mature B cells. Deregulated or reduced Pax5 activity has also been implicated in B-cell malignancies both in human disease and mouse models. Candidate gene approaches and biochemical analysis have revealed that Pax5 regulates B lymphopoiesis by concurrently activating B cell-specific gene expression as well as repressing the expression of genes, many of which are associated with non-B cell lineages. These studies have been recently complemented with more exhaustive microarray studies, which have identified and validated a large panel of Pax5 target genes. These target genes reveal a gene regulatory network, with Pax5 at its centre that controls the B-cell gene expression programme.
Original language | English |
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Pages (from-to) | 47-53 |
Journal | Immunology & Cell Biology |
Volume | 86 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2008 |
Keywords / Materials (for Non-textual outputs)
- Animals
- B-Cell-Specific Activator Protein/genetics
- B-Cell-Specific Activator Protein/immunology
- B-Cell-Specific Activator Protein/metabolism
- B-Lymphocyte Subsets/cytology
- B-Lymphocyte Subsets/immunology
- B-Lymphocytes/cytology
- B-Lymphocytes/immunology
- B-Lymphocytes/metabolism
- Cell Lineage/immunology
- Down-Regulation
- Gene Expression Profiling
- Gene Expression Regulation, Developmental/immunology
- Humans
- Immunoglobulin Class Switching/genetics
- Lymphocyte Activation/genetics
- Lymphocyte Activation/immunology
- Mice
- Receptor, Notch1/genetics
- Receptor, Notch1/immunology
- Up-Regulation
- fms-Like Tyrosine Kinase 3/genetics
- fms-Like Tyrosine Kinase 3/immunology