The regulation of the B-cell gene expression programme by Pax5.

ML Holmes, Clare Pridans, SL Nutt

Research output: Contribution to journalArticlepeer-review

Abstract

The activity of the transcription factor paired box gene 5 (Pax5) is essential for many aspects of B lymphopoiesis including the initial commitment to the lineage, immunoglobulin rearrangement, pre-B cell receptor signalling and maintaining cell identity in mature B cells. Deregulated or reduced Pax5 activity has also been implicated in B-cell malignancies both in human disease and mouse models. Candidate gene approaches and biochemical analysis have revealed that Pax5 regulates B lymphopoiesis by concurrently activating B cell-specific gene expression as well as repressing the expression of genes, many of which are associated with non-B cell lineages. These studies have been recently complemented with more exhaustive microarray studies, which have identified and validated a large panel of Pax5 target genes. These target genes reveal a gene regulatory network, with Pax5 at its centre that controls the B-cell gene expression programme.
Original languageEnglish
Pages (from-to)47-53
JournalImmunology and Cell Biology
Volume86
Issue number1
DOIs
Publication statusPublished - 2008

Keywords

  • Animals
  • B-Cell-Specific Activator Protein/genetics
  • B-Cell-Specific Activator Protein/immunology
  • B-Cell-Specific Activator Protein/metabolism
  • B-Lymphocyte Subsets/cytology
  • B-Lymphocyte Subsets/immunology
  • B-Lymphocytes/cytology
  • B-Lymphocytes/immunology
  • B-Lymphocytes/metabolism
  • Cell Lineage/immunology
  • Down-Regulation
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental/immunology
  • Humans
  • Immunoglobulin Class Switching/genetics
  • Lymphocyte Activation/genetics
  • Lymphocyte Activation/immunology
  • Mice
  • Receptor, Notch1/genetics
  • Receptor, Notch1/immunology
  • Up-Regulation
  • fms-Like Tyrosine Kinase 3/genetics
  • fms-Like Tyrosine Kinase 3/immunology

Fingerprint

Dive into the research topics of 'The regulation of the B-cell gene expression programme by Pax5.'. Together they form a unique fingerprint.

Cite this