The regulation of vascular endothelial growth factor by hypoxia and prostaglandin F₂α during human endometrial repair

Jacqueline A Maybin; Nikhil Hirani; Pamela Brown; Henry N Jabbour; Hilary O D Critchley

doi:10.1210/jc.2010-2971

The regulation of vascular endothelial growth factor by hypoxia and prostaglandin F₂α during human endometrial repair

Jacqueline A Maybin, Nikhil Hirani, Pamela Brown, Henry N Jabbour, Hilary O D Critchley

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The human endometrium has an exceptional capacity for repeated repair after menses, but its regulation remains undefined. Premenstrually, progesterone levels fall and prostaglandin (PG) F₂α synthesis increases, causing spiral arteriole constriction. We hypothesized that progesterone withdrawal, PGF₂α, and hypoxia increase vascular endothelial growth factor (VEGF), an endometrial repair factor.

Original language	English
Pages (from-to)	2475-83
Number of pages	9
Journal	The Journal of Clinical Endocrinology & Metabolism (JCEM)
Volume	96
Issue number	8
DOIs	https://doi.org/10.1210/jc.2010-2971
Publication status	Published - 2011

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10.1210/jc.2010-2971

The regulation of vascular endothelial growth factor by hypoxia and prostaglandin F₂α during human endometrial repair
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/us/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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http://jcem.endojournals.org/content/96/8/2475

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title = "The regulation of vascular endothelial growth factor by hypoxia and prostaglandin F₂α during human endometrial repair",

abstract = "The human endometrium has an exceptional capacity for repeated repair after menses, but its regulation remains undefined. Premenstrually, progesterone levels fall and prostaglandin (PG) F₂α synthesis increases, causing spiral arteriole constriction. We hypothesized that progesterone withdrawal, PGF₂α, and hypoxia increase vascular endothelial growth factor (VEGF), an endometrial repair factor.",

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AU - Jabbour, Henry N

AU - Critchley, Hilary O D

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AB - The human endometrium has an exceptional capacity for repeated repair after menses, but its regulation remains undefined. Premenstrually, progesterone levels fall and prostaglandin (PG) F₂α synthesis increases, causing spiral arteriole constriction. We hypothesized that progesterone withdrawal, PGF₂α, and hypoxia increase vascular endothelial growth factor (VEGF), an endometrial repair factor.

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The regulation of vascular endothelial growth factor by hypoxia and prostaglandin F₂α during human endometrial repair

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Hypoxia inducible factor (HIF1) an endometrial remodelling: relevance to menstrual bleeding

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The regulation of vascular endothelial growth factor by hypoxia and prostaglandin F₂α during human endometrial repair

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Hypoxia inducible factor (HIF1) an endometrial remodelling: relevance to menstrual bleeding

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