The Relationship Between Metabolic Risk Factors and Incident Cardiovascular Disease in Europeans, South Asians, and African Caribbeans SABRE (Southall and Brent Revisited)-A Prospective Population-Based Study: SABRE (Southall and Brent Revisited) -a prospective population-based study

Therese Tillin, Alun D. Hughes, Jamil Mayet, Peter Whincup, Naveed Sattar, Nita G. Forouhi, Paul M. McKeigue, Nish Chaturvedi

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives This study sought to determine whether ethnic differences in diabetes, dyslipidemia, and ectopic fat deposition account for ethnic differences in incident cardiovascular disease.

Background Coronary heart disease risks are elevated in South Asians and are lower in African Caribbeans compared with Europeans. These ethnic differences map to lipid patterns and ectopic fat deposition.

Methods Cardiovascular risk factors were assessed in 2,049 Europeans, 1,517 South Asians, and 630 African Caribbeans from 1988 through 1991 (mean age: 52.4 +/- 6.9 years). Fatal and nonfatal events were captured over a median 20.5-year follow-up. Subhazard ratios (SHR) were calculated using competing risks regression.

Results Baseline diabetes prevalence was more than 3 times greater in South Asians and African Caribbeans than in Europeans. South Asians were more and African Caribbeans were less centrally obese and dyslipidemic than Europeans. Compared with Europeans, coronary heart disease incidence was greater in South Asians and less in African Caribbeans. The age-and sex-adjusted South Asian versus European SHR was 1.70 (95% confidence interval [CI]: 1.52 to 1.91, p <0.001) and remained significant (1.45, 95% CI: 1.28 to 1.64, p <0.001) when adjusted for waist-to-hip ratio. The African Caribbean versus European age-and sex-adjusted SHR of 0.64 (95% CI: 0.52 to 0.79, p <0.001) remained significant when adjusted for high-density lipoprotein and low-density lipoprotein cholesterol (0.74, 95% CI: 0.60 to 0.92, p = 0.008). Compared with Europeans, South Asians and African Caribbeans experienced more strokes (age-and sex-adjusted SHR: 1.45 [95% CI: 1.17 to 1.80, p = 0.001] and 1.50 [95% CI: 1.13 to 2.00, p = 0.005], respectively), and this differential was more marked in those with diabetes (age-adjusted SHR: 1.97 [95% CI: 1.16 to 3.35, p = 0.038 for interaction] and 2.21 [95% CI: 1.14 to 4.30, p = 0.019 for interaction]).

Conclusions Ethnic differences in measured metabolic risk factors did not explain differences in coronary heart disease incidence. The apparently greater association between diabetes and stroke risk in South Asians and African Caribbeans compared with Europeans merits further study. (J Am Coll Cardiol 2013;61:1777-86) (C) 2013 by the American College of Cardiology Foundation

Original languageEnglish
Pages (from-to)1777-1786
Number of pages10
JournalJournal of the American College of Cardiology
Volume61
Issue number17
DOIs
Publication statusPublished - 30 Apr 2013

Keywords

  • MYOCARDIAL-INFARCTION
  • BLOOD-PRESSURE
  • STROKE
  • UK
  • INDIVIDUALS
  • ETHNICITY
  • COUNTRIES
  • stroke
  • coronary heart disease
  • MORTALITY
  • incidence
  • EPIDEMIOLOGY
  • ethnicity
  • CORONARY-HEART-DISEASE

Cite this