The relationship between telomere length and mortality risk in non-model vertebrate systems: A meta-analysis

Rachael Wilbourn, Joshua Moatt, Hannah Froy, Craig A. Walling, Daniel H. Nussey, Jelle J. Boonekamp

Research output: Contribution to journalArticlepeer-review

Abstract

Telomere length (TL) has become a biomarker of increasing interest within ecology and evolutionary biology, and has been found to predict subsequent survival in some recent avian studies but not others.
Here, we undertake the first formal meta-analysis to test whether there is an overall association between TL and subsequent mortality risk in vertebrates other than humans and model laboratory rodents. We identified 27 suitable studies and obtained standardised estimates of the hazard ratio associated with TL from each. We performed a meta-analysis on these estimates and found an overall significant negative association implying that short telomeres are associated with increased mortality risk, which was robust to evident publication bias. While we found that heterogeneity in the hazard ratios was not explained by sex, follow-up period, maximum lifespan or the age group of the study animals, the TL-mortality risk association was stronger in studies using qPCR compared to TRF methodologies. Our results provide support for a consistent association between short telomeres and increased mortality risk in birds, but also highlight the need for more research into non-avian vertebrates and the reasons why different telomere measurement methods may yield different results.
This article is part of the theme issue ‘Understanding diversity in telomere dynamics’.
Original languageEnglish
Article number20160447
Number of pages10
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume373
Issue number1741
Early online date15 Jan 2018
DOIs
Publication statusPublished - 5 Mar 2018

Keywords

  • survival
  • longevity
  • systematic review
  • wild
  • publication bias

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