The release of nitric oxide from S-nitrosothiols promotes angiogenesis

Bahjat Al-Ani, Peter W Hewett, Suborna Ahmed, Melissa Cudmore, Takeshi Fujisawa, Shakil Ahmad, Asif Ahmed

Research output: Contribution to journalArticlepeer-review

Abstract

Free nitric oxide (NO) reacts with sulphydryl residues to form S-nitrosothiols, which act as NO reservoirs. We sought to determine whether thiol-preserving agents and antioxidants, such as dithiothreitol (DTT) and vitamin C, induce NO release from S-nitrosylated proteins in endothelial cell cultures to promote angiogenesis.
Original languageEnglish
Pages (from-to)e25
JournalPLoS ONE
Volume1
DOIs
Publication statusPublished - 2006

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