The relevance of a hypoxic tumour microenvironment in prostate cancer

Grant D Stewart, James A Ross, Duncan B McLaren, Christopher C Parker, Fouad K Habib, Antony C P Riddick

Research output: Contribution to journalArticlepeer-review

Abstract

Research into the hypoxic tumour microenvironment is accelerating and the reversal of hypoxia is increasingly being suggested as a mechanism for improving cancer treatment. Recent studies have suggested that hypoxia is also a feature in prostate cancer and is associated with a poor prognosis. Hypoxia has been shown to cause radio-resistance and hence hamper one of the major treatments for prostate cancer. However, unlike other solid tumours, such as cervical and head-and-neck cancer, there are inconsistencies and unanswered questions about the relevance of hypoxia in prostate cancer. This review outlines the role of low-oxygen conditions in prostate cancer and the areas where further studies are required.
Original languageEnglish
Article number105
Pages (from-to)8-13
Number of pages6
JournalBJU International
Volume105
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Cell Hypoxia
  • Cell Proliferation
  • Cell Survival
  • Humans
  • Hypoxia-Inducible Factor 1
  • Male
  • Prostatic Neoplasms
  • Vascular Endothelial Growth Factor A

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