Abstract / Description of output
Research into the hypoxic tumour microenvironment is accelerating and the reversal of hypoxia is increasingly being suggested as a mechanism for improving cancer treatment. Recent studies have suggested that hypoxia is also a feature in prostate cancer and is associated with a poor prognosis. Hypoxia has been shown to cause radio-resistance and hence hamper one of the major treatments for prostate cancer. However, unlike other solid tumours, such as cervical and head-and-neck cancer, there are inconsistencies and unanswered questions about the relevance of hypoxia in prostate cancer. This review outlines the role of low-oxygen conditions in prostate cancer and the areas where further studies are required.
Original language | English |
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Article number | 105 |
Pages (from-to) | 8-13 |
Number of pages | 6 |
Journal | BJU International |
Volume | 105 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2010 |
Keywords / Materials (for Non-textual outputs)
- Cell Hypoxia
- Cell Proliferation
- Cell Survival
- Humans
- Hypoxia-Inducible Factor 1
- Male
- Prostatic Neoplasms
- Vascular Endothelial Growth Factor A