The respiratory microbiome in childhood asthma

Gina J Van Beveren, Hager Said, Marlies A van Houten, Debby Bogaert*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Asthma is the most prevalent non-communicable disease in childhood, characterized by reversible airway constriction and inflammation of the lower airways. The respiratory tract constitutes of the upper and lower airways and are lined with a diverse community of microbes. The composition and density of the respiratory microbiome differs across the respiratory tract, with microbes adapting to the gradually changing physiology of the environment. Over the past decade, both the upper- and lower respiratory microbiome have been implicated in the etiology and disease course of asthma, as well as its severity and phenotype. We have reviewed the literature on the role of the respiratory microbiome in asthma, making a careful distinction between the relationship of the microbiome with development of childhood asthma and its relationship with the disease course, while accounting for age and the microbial niches studied. Furthermore, we assessed the literature regarding the underlying asthma endotypes and the impact of the microbiome on the host-immune response. We’ve identified distinct microbial signatures across the respiratory tract associated with asthma development, asthma stability and severity. These data suggest that the respiratory microbiome may be important for asthma development and severity, and therefore a potential target for future microbiome-based preventive and treatment strategies.
Original languageEnglish
Pages (from-to)1352-1367
JournalJournal of Allergy and Clinical Immunology
Volume152
Issue number6
DOIs
Publication statusPublished - 5 Dec 2023

Keywords / Materials (for Non-textual outputs)

  • Asthma
  • wheeze
  • respiratory microbiome
  • pediatric

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