The Rise of Adaptive Platform Trials in Critical Care

PRACTICAL, PANTHER, TRAITS, INCEPT, and REMAP-CAP investigators; Lieuwe D J Bos; Carolyn Calfee; Andrea Castellvi-Font; Victoria Cornelius; Lennie PG Derde; Annemarie B Docherty; Eddy Fan; Niall Ferguson; Ewan Goligher; Anthony C Gordon; Anders Granholm; Michael O Harhay; Anna Heath; Maj-Brit Norregaard Kjaer; Patrick R Lawler; Nazir I Lone; Danny F. McAuley; Morten Hylander Møller; Laveena Munshi; Srinivas Murthy; Alistair D Nichol; Anders Perner; Kiran Reddy; Bram Rochwerg; Kathy Rowan; Sarina Sahetya; Manu Shankar-Hari; Steve Webb; Christopher J Weir; Ryan Zarychanski

doi:10.1164/rccm.202401-0101CP

The Rise of Adaptive Platform Trials in Critical Care

PRACTICAL, PANTHER, TRAITS, INCEPT, and REMAP-CAP investigators, Lieuwe D J Bos, Carolyn Calfee, Andrea Castellvi-Font, Victoria Cornelius, Lennie PG Derde, Annemarie B Docherty, Eddy Fan, Niall Ferguson, Ewan Goligher^*, Anthony C Gordon, Anders Granholm, Michael O Harhay, Anna Heath, Maj-Brit Norregaard Kjaer, Patrick R Lawler, Nazir I Lone, Danny F. McAuley, Morten Hylander Møller, Laveena MunshiSrinivas Murthy, Alistair D Nichol, Anders Perner, Kiran Reddy, Bram Rochwerg, Kathy Rowan, Sarina Sahetya, Manu Shankar-Hari, Steve Webb, Christopher J Weir, Ryan Zarychanski

^*Corresponding author for this work

Research output: Contribution to journal › Editorial › peer-review

Abstract / Description of output

As durable learning research systems, adaptive platform trials represent a transformative new approach to accelerating clinical evaluation and discovery in critical care. This Perspective provides a brief introduction to the concept of adaptive platform trials, describes several established and emerging platforms in critical care, and surveys some opportunities and challenges for their implementation and impact.

Original language	English
Pages (from-to)	491-496
Number of pages	6
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	209
Issue number	5
DOIs	https://doi.org/10.1164/rccm.202401-0101CP
Publication status	Published - 1 Mar 2024

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PRACTICAL, PANTHER, TRAITS, INCEPT, and REMAP-CAP investigators, Bos, L. D. J., Calfee, C., Castellvi-Font, A., Cornelius, V., Derde, L. PG., Docherty, A. B., Fan, E., Ferguson, N., Goligher, E., Gordon, A. C., Granholm, A., Harhay, M. O., Heath, A., Norregaard Kjaer, M.-B., Lawler, P. R., Lone, N. I., McAuley, D. F., Møller, M. H., ... Zarychanski, R. (2024). The Rise of Adaptive Platform Trials in Critical Care. American Journal of Respiratory and Critical Care Medicine, 209(5), 491-496. https://doi.org/10.1164/rccm.202401-0101CP

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title = "The Rise of Adaptive Platform Trials in Critical Care",

abstract = "As durable learning research systems, adaptive platform trials represent a transformative new approach to accelerating clinical evaluation and discovery in critical care. This Perspective provides a brief introduction to the concept of adaptive platform trials, describes several established and emerging platforms in critical care, and surveys some opportunities and challenges for their implementation and impact.",

author = "{PRACTICAL, PANTHER, TRAITS, INCEPT, and REMAP-CAP investigators} and Bos, {Lieuwe D J} and Carolyn Calfee and Andrea Castellvi-Font and Victoria Cornelius and Derde, {Lennie PG} and Docherty, {Annemarie B} and Eddy Fan and Niall Ferguson and Ewan Goligher and Gordon, {Anthony C} and Anders Granholm and Harhay, {Michael O} and Anna Heath and {Norregaard Kjaer}, Maj-Brit and Lawler, {Patrick R} and Lone, {Nazir I} and McAuley, {Danny F.} and M{\o}ller, {Morten Hylander} and Laveena Munshi and Srinivas Murthy and Nichol, {Alistair D} and Anders Perner and Kiran Reddy and Bram Rochwerg and Kathy Rowan and Sarina Sahetya and Manu Shankar-Hari and Steve Webb and Weir, {Christopher J} and Ryan Zarychanski",

year = "2024",

month = mar,

day = "1",

doi = "10.1164/rccm.202401-0101CP",

language = "English",

volume = "209",

pages = "491--496",

journal = "American Journal of Respiratory and Critical Care Medicine",

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PRACTICAL, PANTHER, TRAITS, INCEPT, and REMAP-CAP investigators, Bos, LDJ, Calfee, C, Castellvi-Font, A, Cornelius, V, Derde, LPG, Docherty, AB, Fan, E, Ferguson, N, Goligher, E, Gordon, AC, Granholm, A, Harhay, MO, Heath, A, Norregaard Kjaer, M-B, Lawler, PR, Lone, NI, McAuley, DF, Møller, MH, Munshi, L, Murthy, S, Nichol, AD, Perner, A, Reddy, K, Rochwerg, B, Rowan, K, Sahetya, S, Shankar-Hari, M, Webb, S, Weir, CJ & Zarychanski, R 2024, 'The Rise of Adaptive Platform Trials in Critical Care', American Journal of Respiratory and Critical Care Medicine, vol. 209, no. 5, pp. 491-496. https://doi.org/10.1164/rccm.202401-0101CP

TY - JOUR

T1 - The Rise of Adaptive Platform Trials in Critical Care

AU - PRACTICAL, PANTHER, TRAITS, INCEPT, and REMAP-CAP investigators

AU - Bos, Lieuwe D J

AU - Calfee, Carolyn

AU - Castellvi-Font, Andrea

AU - Cornelius, Victoria

AU - Derde, Lennie PG

AU - Docherty, Annemarie B

AU - Fan, Eddy

AU - Ferguson, Niall

AU - Goligher, Ewan

AU - Gordon, Anthony C

AU - Granholm, Anders

AU - Harhay, Michael O

AU - Heath, Anna

AU - Norregaard Kjaer, Maj-Brit

AU - Lawler, Patrick R

AU - Lone, Nazir I

AU - McAuley, Danny F.

AU - Møller, Morten Hylander

AU - Munshi, Laveena

AU - Murthy, Srinivas

AU - Nichol, Alistair D

AU - Perner, Anders

AU - Reddy, Kiran

AU - Rochwerg, Bram

AU - Rowan, Kathy

AU - Sahetya, Sarina

AU - Shankar-Hari, Manu

AU - Webb, Steve

AU - Weir, Christopher J

AU - Zarychanski, Ryan

PY - 2024/3/1

Y1 - 2024/3/1

N2 - As durable learning research systems, adaptive platform trials represent a transformative new approach to accelerating clinical evaluation and discovery in critical care. This Perspective provides a brief introduction to the concept of adaptive platform trials, describes several established and emerging platforms in critical care, and surveys some opportunities and challenges for their implementation and impact.

AB - As durable learning research systems, adaptive platform trials represent a transformative new approach to accelerating clinical evaluation and discovery in critical care. This Perspective provides a brief introduction to the concept of adaptive platform trials, describes several established and emerging platforms in critical care, and surveys some opportunities and challenges for their implementation and impact.

U2 - 10.1164/rccm.202401-0101CP

DO - 10.1164/rccm.202401-0101CP

M3 - Editorial

SN - 1073-449X

VL - 209

SP - 491

EP - 496

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 5

ER -

The Rise of Adaptive Platform Trials in Critical Care

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