The Rise of Adaptive Platform Trials in Critical Care

PRACTICAL, PANTHER, TRAITS, INCEPT, and REMAP-CAP investigators, Lieuwe D J Bos, Carolyn Calfee, Andrea Castellvi-Font, Victoria Cornelius, Lennie PG Derde, Annemarie B Docherty, Eddy Fan, Niall Ferguson, Ewan Goligher*, Anthony C Gordon, Anders Granholm, Michael O Harhay, Anna Heath, Maj-Brit Norregaard Kjaer, Patrick R Lawler, Nazir I Lone, Danny F. McAuley, Morten Hylander Møller, Laveena MunshiSrinivas Murthy, Alistair D Nichol, Anders Perner, Kiran Reddy, Bram Rochwerg, Kathy Rowan, Sarina Sahetya, Manu Shankar-Hari, Steve Webb, Christopher J Weir, Ryan Zarychanski

*Corresponding author for this work

Research output: Contribution to journalEditorialpeer-review

Abstract / Description of output

As durable learning research systems, adaptive platform trials represent a transformative new approach to accelerating clinical evaluation and discovery in critical care. This Perspective provides a brief introduction to the concept of adaptive platform trials, describes several established and emerging platforms in critical care, and surveys some opportunities and challenges for their implementation and impact.

Original languageEnglish
Pages (from-to)491-496
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number5
Publication statusPublished - 1 Mar 2024


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