The risk of transmitting prion disease by blood or plasma products

Richard Knight

doi:10.1016/j.transci.2010.09.003

The risk of transmitting prion disease by blood or plasma products

Research output: Contribution to journal › Editorial › peer-review

Abstract / Description of output

Various experimental studies have shown infectivity in blood in relation to bovine spongiform encephalitis (BSE) and variant Creutzfeldt-Jakob disease (vCJD). Human to human transmission vCJD infection has been reported via transfusion of non-leukocyte-reduced red cells and, probably, via factor VIII concentrates. A number of precautionary measures are in place but uncertainties remain, especially concerning the number of BSE-infected people in the population. Additional measures such as prion filtration need consideration. (C) 2010 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	387-391
Number of pages	5
Journal	Transfusion and apheresis science
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/j.transci.2010.09.003
Publication status	Published - Dec 2010

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title = "The risk of transmitting prion disease by blood or plasma products",

abstract = "Various experimental studies have shown infectivity in blood in relation to bovine spongiform encephalitis (BSE) and variant Creutzfeldt-Jakob disease (vCJD). Human to human transmission vCJD infection has been reported via transfusion of non-leukocyte-reduced red cells and, probably, via factor VIII concentrates. A number of precautionary measures are in place but uncertainties remain, especially concerning the number of BSE-infected people in the population. Additional measures such as prion filtration need consideration. (C) 2010 Elsevier Ltd. All rights reserved.",

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AB - Various experimental studies have shown infectivity in blood in relation to bovine spongiform encephalitis (BSE) and variant Creutzfeldt-Jakob disease (vCJD). Human to human transmission vCJD infection has been reported via transfusion of non-leukocyte-reduced red cells and, probably, via factor VIII concentrates. A number of precautionary measures are in place but uncertainties remain, especially concerning the number of BSE-infected people in the population. Additional measures such as prion filtration need consideration. (C) 2010 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.transci.2010.09.003

DO - 10.1016/j.transci.2010.09.003

M3 - Editorial

SN - 1473-0502

VL - 43

SP - 387

EP - 391

JO - Transfusion and apheresis science

JF - Transfusion and apheresis science

IS - 3

ER -

The risk of transmitting prion disease by blood or plasma products

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