The risk of transmitting prion disease by blood or plasma products

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Various experimental studies have shown infectivity in blood in relation to bovine spongiform encephalitis (BSE) and variant Creutzfeldt-Jakob disease (vCJD). Human to human transmission vCJD infection has been reported via transfusion of non-leukocyte-reduced red cells and, probably, via factor VIII concentrates. A number of precautionary measures are in place but uncertainties remain, especially concerning the number of BSE-infected people in the population. Additional measures such as prion filtration need consideration. (C) 2010 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)387-391
Number of pages5
JournalTransfusion and apheresis science
Issue number3
Publication statusPublished - Dec 2010


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