The risks of using allogeneic cell lines for vaccine production: The example of Bovine Neonatal Pancytopenia

Lindert Benedictus; Charlotte Bell

doi:10.1080/14760584.2017.1249859

The risks of using allogeneic cell lines for vaccine production: The example of Bovine Neonatal Pancytopenia

Lindert Benedictus, Charlotte Bell

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Bovine neonatal pancytopenia (BNP) is a hemorrhagic disease that emerged in calves across Europe in 2007. Its occurrence is attributed to immunization of the calf’s mother with a vaccine produced using an allogeneic cell line. Vaccine-induced alloantibodies specific for major-histocompatibility class I antigens are transferred from the mother to the calf via colostrum, leading to profound depletion of peripheral blood and bone marrow cells that is often fatal.

Areas covered: Pubmed and Web of Science were used to search for literature relevant to BNP and the use of allogeneic vaccine cell lines. Following a review of the pathology and pathogenesis of this novel condition, we discuss potential risks associated with the use of allogeneic vaccine cell lines.

Expert commentary: Although BNP is associated with a specific vaccine, it highlights safety concerns common to all vaccines produced using allogeneic cell lines. Measures to prevent similar vaccine-induced alloimmune-mediated adverse events in the future are discussed.

Original language	English
Pages (from-to)	65-71
Journal	Expert Review of Vaccines
Volume	16
Issue number	1
Early online date	17 Oct 2016
DOIs	https://doi.org/10.1080/14760584.2017.1249859
Publication status	Published - 2017

Keywords / Materials (for Non-textual outputs)

Vaccine safety
Vaccine production
Alloantibody
Allogeneic
Alloimmune
Bovine
Neonatal Pancytopenia (BNP)
Major Histocompatibility Complex class I (MHC I)
Cell line
Colostrum
Hematopoietic

Access to Document

10.1080/14760584.2017.1249859

The risks of using allogeneic cell lines for vaccine production the example of Bovine Neonatal Pancytopenia
© 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 1.35 MBLicence: Creative Commons: Attribution (CC-BY)

Innate immunity and endemic diseases in livestock species
Collie, D. (Principal Investigator), Beard, P. (Co-investigator), Bishop, S. (Co-investigator), Bronsvoort, M. (Co-investigator), Burt, D. (Co-investigator), Fitzgerald, R. (Co-investigator), Freeman, T. (Co-investigator), Gally, D. (Co-investigator), Gill, A. (Co-investigator), Glass, E. (Co-investigator), Hocking, P. (Co-investigator), Hope, J. (Co-investigator), Hume, D. (Co-investigator), Kaiser, P. (Co-investigator), Mabbott, N. (Co-investigator), McLachlan, G. (Co-investigator), Morrison, L. (Co-investigator), Stevens, J. (Co-investigator), Stevens, M. (Co-investigator) & Watson, M. (Co-investigator)
Biotechnology and Biological Sciences Research Council
1/04/12 → 31/03/17
Project: Research
University of Edinburgh Principal's Career Development Scholarship
Bell, C. (Principal Investigator)
1/09/10 → 30/09/13
Project: University Awarded Project Funding

Cite this

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title = "The risks of using allogeneic cell lines for vaccine production: The example of Bovine Neonatal Pancytopenia",

abstract = "Introduction: Bovine neonatal pancytopenia (BNP) is a hemorrhagic disease that emerged in calves across Europe in 2007. Its occurrence is attributed to immunization of the calf{\textquoteright}s mother with a vaccine produced using an allogeneic cell line. Vaccine-induced alloantibodies specific for major-histocompatibility class I antigens are transferred from the mother to the calf via colostrum, leading to profound depletion of peripheral blood and bone marrow cells that is often fatal. Areas covered: Pubmed and Web of Science were used to search for literature relevant to BNP and the use of allogeneic vaccine cell lines. Following a review of the pathology and pathogenesis of this novel condition, we discuss potential risks associated with the use of allogeneic vaccine cell lines. Expert commentary: Although BNP is associated with a specific vaccine, it highlights safety concerns common to all vaccines produced using allogeneic cell lines. Measures to prevent similar vaccine-induced alloimmune-mediated adverse events in the future are discussed.",

keywords = "Vaccine safety, Vaccine production, Alloantibody, Allogeneic, Alloimmune, Bovine, Neonatal Pancytopenia (BNP), Major Histocompatibility Complex class I (MHC I), Cell line, Colostrum, Hematopoietic",

author = "Lindert Benedictus and Charlotte Bell",

year = "2017",

doi = "10.1080/14760584.2017.1249859",

language = "English",

volume = "16",

pages = "65--71",

journal = "Expert Review of Vaccines",

issn = "1476-0584",

publisher = "Taylor \& Francis",

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AU - Benedictus, Lindert

AU - Bell, Charlotte

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N2 - Introduction: Bovine neonatal pancytopenia (BNP) is a hemorrhagic disease that emerged in calves across Europe in 2007. Its occurrence is attributed to immunization of the calf’s mother with a vaccine produced using an allogeneic cell line. Vaccine-induced alloantibodies specific for major-histocompatibility class I antigens are transferred from the mother to the calf via colostrum, leading to profound depletion of peripheral blood and bone marrow cells that is often fatal. Areas covered: Pubmed and Web of Science were used to search for literature relevant to BNP and the use of allogeneic vaccine cell lines. Following a review of the pathology and pathogenesis of this novel condition, we discuss potential risks associated with the use of allogeneic vaccine cell lines. Expert commentary: Although BNP is associated with a specific vaccine, it highlights safety concerns common to all vaccines produced using allogeneic cell lines. Measures to prevent similar vaccine-induced alloimmune-mediated adverse events in the future are discussed.

AB - Introduction: Bovine neonatal pancytopenia (BNP) is a hemorrhagic disease that emerged in calves across Europe in 2007. Its occurrence is attributed to immunization of the calf’s mother with a vaccine produced using an allogeneic cell line. Vaccine-induced alloantibodies specific for major-histocompatibility class I antigens are transferred from the mother to the calf via colostrum, leading to profound depletion of peripheral blood and bone marrow cells that is often fatal. Areas covered: Pubmed and Web of Science were used to search for literature relevant to BNP and the use of allogeneic vaccine cell lines. Following a review of the pathology and pathogenesis of this novel condition, we discuss potential risks associated with the use of allogeneic vaccine cell lines. Expert commentary: Although BNP is associated with a specific vaccine, it highlights safety concerns common to all vaccines produced using allogeneic cell lines. Measures to prevent similar vaccine-induced alloimmune-mediated adverse events in the future are discussed.

KW - Vaccine safety

KW - Vaccine production

KW - Alloantibody

KW - Allogeneic

KW - Alloimmune

KW - Bovine

KW - Neonatal Pancytopenia (BNP)

KW - Major Histocompatibility Complex class I (MHC I)

KW - Cell line

KW - Colostrum

KW - Hematopoietic

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DO - 10.1080/14760584.2017.1249859

M3 - Article

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JF - Expert Review of Vaccines

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The risks of using allogeneic cell lines for vaccine production: The example of Bovine Neonatal Pancytopenia

Abstract

Keywords / Materials (for Non-textual outputs)

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Projects

Innate immunity and endemic diseases in livestock species

University of Edinburgh Principal's Career Development Scholarship

Cite this