The role and therapeutic potential of the autotaxin-lysophosphatidate signalling axis in breast cancer

Katy Teo, Valerie G. Brunton*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

ATX (autotaxin) is a secreted lysophospholipase capable of catalysing the formation of the bioactive lipid mediator LPA (lysophosphatidate) from LPC (lysophosphatidylcholine). The ATX LPA signalling axis plays an important role in both normal physiology and disease pathogenesis, including cancer. In a number of different human cancers, expression of ATX and the G-protein-coupled LPARs (lysophosphatidic acid receptors) have been shown to be elevated and their activation regulates many processes central to tumorigenesis, including proliferation, invasion, migration and angiogenesis. The present review provides an overview of the ATX LPA signalling axis and collates current knowledge regarding its specific role in breast cancer. The potential manipulation of this pathway to facilitate diagnosis and treatment is also discussed.

Original languageEnglish
Pages (from-to)157-165
Number of pages9
JournalBiochemical Journal
Volume463
Issue number1
DOIs
Publication statusPublished - 1 Oct 2014

Keywords

  • autotaxin
  • breast cancer
  • lysophosphatidic acid
  • metastasis
  • therapy
  • LYSOPHOSPHOLIPASE-D ACTIVITY
  • FIBROBLAST-LIKE SYNOVIOCYTES
  • CYCLIC PHOSPHATIDIC-ACID
  • TUMOR-CELL MOTILITY
  • LPA RECEPTORS
  • BIOCHEMICAL-CHARACTERIZATION
  • SPHINGOSINE 1-PHOSPHATE
  • RHEUMATOID-ARTHRITIS
  • HYDROPHOBIC POCKET
  • CRYSTAL-STRUCTURE

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