The role of Atonal transcription factors in the development of mechanosensitive cells

Andrew P Jarman; Andrew K Groves

doi:10.1016/j.semcdb.2013.03.010

The role of Atonal transcription factors in the development of mechanosensitive cells

Andrew P Jarman, Andrew K Groves

Deanery of Biomedical Sciences

Research output: Contribution to journal › Literature review › peer-review

Abstract / Description of output

Mechanosensation is an evolutionarily ancient sensory modality seen in all main animal groups. Mechanosensation can be mediated by sensory neurons or by dedicated receptor cells that form synapses with sensory neurons. Evidence over the last 15-20 years suggests that both classes of mechanosensory cells can be specified by the atonal class of basic helix-loop-helix transcription factors. In this review we discuss recent work addressing how atonal factors specify mechanosensitive cells in vertebrates and invertebrates, and how the redeployment of these factors underlies the regeneration of mechanosensitive cells in some vertebrate groups.

Original language	English
Journal	Seminars in Cell and Developmental Biology
DOIs	https://doi.org/10.1016/j.semcdb.2013.03.010
Publication status	Published - 30 Mar 2013

Access to Document

10.1016/j.semcdb.2013.03.010

The role of Atonal transcription factors in the development of mechanosensitive cells
This is a PDF file of an unedited manuscript that has been accepted for publication.
Accepted author manuscript, 477 KB

http://www.sciencedirect.com/science/article/pii/S1084952113000463

Cite this

@article{fcb458ce6051418299c77b3998760cc3,

title = "The role of Atonal transcription factors in the development of mechanosensitive cells",

abstract = "Mechanosensation is an evolutionarily ancient sensory modality seen in all main animal groups. Mechanosensation can be mediated by sensory neurons or by dedicated receptor cells that form synapses with sensory neurons. Evidence over the last 15-20 years suggests that both classes of mechanosensory cells can be specified by the atonal class of basic helix-loop-helix transcription factors. In this review we discuss recent work addressing how atonal factors specify mechanosensitive cells in vertebrates and invertebrates, and how the redeployment of these factors underlies the regeneration of mechanosensitive cells in some vertebrate groups.",

author = "Jarman, {Andrew P} and Groves, {Andrew K}",

year = "2013",

month = mar,

day = "30",

doi = "10.1016/j.semcdb.2013.03.010",

language = "English",

journal = "Seminars in Cell and Developmental Biology",

issn = "1096-3634",

publisher = "Elsevier",

}

TY - JOUR

T1 - The role of Atonal transcription factors in the development of mechanosensitive cells

AU - Jarman, Andrew P

AU - Groves, Andrew K

PY - 2013/3/30

Y1 - 2013/3/30

N2 - Mechanosensation is an evolutionarily ancient sensory modality seen in all main animal groups. Mechanosensation can be mediated by sensory neurons or by dedicated receptor cells that form synapses with sensory neurons. Evidence over the last 15-20 years suggests that both classes of mechanosensory cells can be specified by the atonal class of basic helix-loop-helix transcription factors. In this review we discuss recent work addressing how atonal factors specify mechanosensitive cells in vertebrates and invertebrates, and how the redeployment of these factors underlies the regeneration of mechanosensitive cells in some vertebrate groups.

AB - Mechanosensation is an evolutionarily ancient sensory modality seen in all main animal groups. Mechanosensation can be mediated by sensory neurons or by dedicated receptor cells that form synapses with sensory neurons. Evidence over the last 15-20 years suggests that both classes of mechanosensory cells can be specified by the atonal class of basic helix-loop-helix transcription factors. In this review we discuss recent work addressing how atonal factors specify mechanosensitive cells in vertebrates and invertebrates, and how the redeployment of these factors underlies the regeneration of mechanosensitive cells in some vertebrate groups.

U2 - 10.1016/j.semcdb.2013.03.010

DO - 10.1016/j.semcdb.2013.03.010

M3 - Literature review

C2 - 23548731

SN - 1096-3634

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

ER -

The role of Atonal transcription factors in the development of mechanosensitive cells

Abstract / Description of output

Access to Document

Fingerprint

Cite this