The role of chromatin modifications in progression through mouse meiotic prophase

James H Crichton, Christopher J Playfoot, Ian R Adams

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Meiosis is a key event in gametogenesis that generates new combinations of genetic information and is required to reduce the chromosome content of the gametes. Meiotic chromosomes undergo a number of specialised events during prophase to allow meiotic recombination, homologous chromosome synapsis and reductional chromosome segregation to occur. In mammalian cells, DNA physically associates with histones to form chromatin, which can be modified by methylation, phosphorylation, ubiquitination and acetylation to help regulate higher order chromatin structure, gene expression, and chromosome organisation. Recent studies have identified some of the enzymes responsible for generating chromatin modifications in meiotic mammalian cells, and shown that these chromatin modifying enzymes are required for key meiosis-specific events that occur during meiotic prophase. This review will discuss the role of chromatin modifications in meiotic recombination, homologous chromosome synapsis and regulation of meiotic gene expression in mammals.

Original languageEnglish
Pages (from-to)97-106
Number of pages10
JournalJournal of Genetics and Genomics
Volume41
Issue number3
DOIs
Publication statusPublished - 20 Mar 2014

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