The role of E-cadherin in low-grade ductal breast tumourigenesis

Rebecca Roylance, Stavroula Droufakou, Patricia Gorman, Cheryl Gillett, Ian R Hart, Andrew Hanby, Ian Tomlinson

Research output: Contribution to journalArticlepeer-review


Grade I invasive ductal breast carcinomas have a specific pattern of genetic aberrations, namely gain of 1q and loss of 16q. This pattern is very similar to the changes seen in invasive lobular breast carcinomas (ILCs). The gene on 16q involved in ILC is known to be E-cadherin (CDH1). This study has investigated whether the same gene is responsible for grade I invasive ductal carcinoma (IDC), using allele imbalance analysis, mutation screening, and immunohistochemistry (IHC). The data suggest that despite the shared pattern of genetic aberrations seen in grade I IDC and ILC, CDH1 is not the target gene in low-grade ductal tumourigenesis
Original languageEnglish
Pages (from-to)53-58
JournalThe Journal of Pathology
Issue number1
Publication statusPublished - 1 May 2003


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