The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

Gordon W McLean, Neil O Carragher, Egle Avizienyte, Jeff Evans, Valerie G Brunton, Margaret C Frame

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell proliferation, cell survival and cell migration. Given that the development of malignancy is often associated with perturbations in these processes, it is not surprising that FAK activity is altered in cancer cells. Mouse models have shown that FAK is involved in tumour formation and progression, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target.
Original languageEnglish
Pages (from-to)505-15
Number of pages11
JournalNature Reviews Cancer
Issue number7
Publication statusPublished - Jul 2005

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Cell Movement
  • Cell Proliferation
  • Cell Survival
  • Disease Progression
  • Focal Adhesion Kinase 1
  • Focal Adhesion Protein-Tyrosine Kinases
  • Humans
  • Mice
  • Models, Animal
  • Neoplasms
  • Protein-Tyrosine Kinases
  • Signal Transduction


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