The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

Gordon W McLean; Neil O Carragher; Egle Avizienyte; Jeff Evans; Valerie G Brunton; Margaret C Frame

doi:10.1038/nrc1647

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

Gordon W McLean, Neil O Carragher, Egle Avizienyte, Jeff Evans, Valerie G Brunton, Margaret C Frame

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell proliferation, cell survival and cell migration. Given that the development of malignancy is often associated with perturbations in these processes, it is not surprising that FAK activity is altered in cancer cells. Mouse models have shown that FAK is involved in tumour formation and progression, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target.

Original language	English
Pages (from-to)	505-15
Number of pages	11
Journal	Nature Reviews Cancer
Volume	5
Issue number	7
DOIs	https://doi.org/10.1038/nrc1647
Publication status	Published - Jul 2005

Keywords / Materials (for Non-textual outputs)

Animals
Cell Movement
Cell Proliferation
Cell Survival
Disease Progression
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases
Humans
Mice
Models, Animal
Neoplasms
Protein-Tyrosine Kinases
Signal Transduction

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title = "The role of focal-adhesion kinase in cancer - a new therapeutic opportunity",

abstract = "Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell proliferation, cell survival and cell migration. Given that the development of malignancy is often associated with perturbations in these processes, it is not surprising that FAK activity is altered in cancer cells. Mouse models have shown that FAK is involved in tumour formation and progression, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target.",

keywords = "Animals, Cell Movement, Cell Proliferation, Cell Survival, Disease Progression, Focal Adhesion Kinase 1, Focal Adhesion Protein-Tyrosine Kinases, Humans, Mice, Models, Animal, Neoplasms, Protein-Tyrosine Kinases, Signal Transduction",

author = "McLean, {Gordon W} and Carragher, {Neil O} and Egle Avizienyte and Jeff Evans and Brunton, {Valerie G} and Frame, {Margaret C}",

year = "2005",

month = jul,

doi = "10.1038/nrc1647",

language = "English",

volume = "5",

pages = "505--15",

journal = "Nature Reviews Cancer",

issn = "1474-175X",

publisher = "Nature Publishing Group",

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T1 - The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

AU - McLean, Gordon W

AU - Carragher, Neil O

AU - Avizienyte, Egle

AU - Evans, Jeff

AU - Brunton, Valerie G

AU - Frame, Margaret C

PY - 2005/7

Y1 - 2005/7

N2 - Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell proliferation, cell survival and cell migration. Given that the development of malignancy is often associated with perturbations in these processes, it is not surprising that FAK activity is altered in cancer cells. Mouse models have shown that FAK is involved in tumour formation and progression, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target.

AB - Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell proliferation, cell survival and cell migration. Given that the development of malignancy is often associated with perturbations in these processes, it is not surprising that FAK activity is altered in cancer cells. Mouse models have shown that FAK is involved in tumour formation and progression, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target.

KW - Animals

KW - Cell Movement

KW - Cell Proliferation

KW - Cell Survival

KW - Disease Progression

KW - Focal Adhesion Kinase 1

KW - Focal Adhesion Protein-Tyrosine Kinases

KW - Humans

KW - Mice

KW - Models, Animal

KW - Neoplasms

KW - Protein-Tyrosine Kinases

KW - Signal Transduction

U2 - 10.1038/nrc1647

DO - 10.1038/nrc1647

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SN - 1474-175X

VL - 5

SP - 505

EP - 515

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 7

ER -

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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