The role of functional dopamine-transporter SPECT imaging in parkinsonian syndromes, part 2

T C Booth, M Nathan, A D Waldman, A-M Quigley, A H Schapira, J Buscombe

Research output: Contribution to journalArticlepeer-review

Abstract

SUMMARY: The functional imaging technique most widely used in European clinics to differentiate a true parkinsonian syndrome from vascular parkinsonism, drug-induced changes, or essential tremor is dopamine-transporter SPECT. This technique commonly reports dopamine-transporter function, with decreasing striatal uptake demonstrating increasingly severe disease. The strength of dopamine-transporter SPECT is that nigrostriatal degeneration is observed in both clinically inconclusive parkinsonism and early, even premotor, disease. In this clinical review (Part 2), we present the dopamine-transporter SPECT findings in a variety of neurodegenerative diseases, including multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies. The findings in vascular parkinsonism, drug-induced parkinsonism, and essential tremor are also described. It is hoped that this technique will be the forerunner of a range of routinely used, process-specific ligands that can identify early degenerative disease and subsequently guide disease-modifying interventions.

Original languageEnglish
Pages (from-to)236-44
Number of pages9
JournalAmerican Journal of Neuroradiology
Volume36
Issue number2
DOIs
Publication statusPublished - Feb 2015
Externally publishedYes

Keywords

  • Corpus Striatum
  • Dopamine Plasma Membrane Transport Proteins
  • Essential Tremor
  • Humans
  • Lewy Body Disease
  • Multiple System Atrophy
  • Parkinsonian Disorders
  • Supranuclear Palsy, Progressive
  • Tomography, Emission-Computed, Single-Photon
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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