The role of fungi in fungal keratitis

Bethany Mills; Naveen Radhakrishnan; Siva Ganesa Karthikeyan Rajapandian; Gunasekaran Rameshkumar; Prajna Lalitha; N. Venkatesh Prajna

doi:10.1016/j.exer.2020.108372

The role of fungi in fungal keratitis

Bethany Mills, Naveen Radhakrishnan, Siva Ganesa Karthikeyan Rajapandian, Gunasekaran Rameshkumar, Prajna Lalitha, N. Venkatesh Prajna

Research output: Contribution to journal › Article › peer-review

Abstract

Fungal keratitis (FK) accounts for approximately half of the microbial keratitis encountered in low middle income countries (LMICs) and predominantly affect the working rural-poor. FK causes significant morbidity with the majority of patients left with moderate or worse visual impairment and approximately 25 % requiring expensive and often unsuccessful surgical interventions. The severity of FK and the resultant corneal damage or resolution can be attributed to i) the virulence and bioburden of the fungal pathogen, ii) the host defense mechanism and immune response and iii) sub-optimal diagnostics and anti-fungal treatment strategies. This review provides a comprehensive overview of the multifaceted components that drive FK progression and resolution, highlighting where knowledge gaps exist and areas that warrant further research.

Original language	English
Pages (from-to)	108372
Journal	Experimental Eye Research
DOIs	https://doi.org/10.1016/j.exer.2020.108372
Publication status	Published - 26 Nov 2020

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10.1016/j.exer.2020.108372

Biology of fungal keratitis final_submitted
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Accepted author manuscript, 1.68 MB

https://linkinghub.elsevier.com/retrieve/pii/S0014483520306308

IRC Next Steps Plus: Photonic Pathogen Theranostics - Point-of-care image guided photonic therapy of bacterial and fungal infection?
Dhaliwal, K. (Principal Investigator), Bradley, M. (Co-investigator), Harrison, E. (Co-investigator), Megia Fernandez, A. (Co-investigator), Mills, B. (Co-investigator), Walsh, T. (Co-investigator) & Williams, G. (Co-investigator)
EPSRC
1/07/19 → 30/06/23
Project: Research

Cite this

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title = "The role of fungi in fungal keratitis",

abstract = "Fungal keratitis (FK) accounts for approximately half of the microbial keratitis encountered in low middle income countries (LMICs) and predominantly affect the working rural-poor. FK causes significant morbidity with the majority of patients left with moderate or worse visual impairment and approximately 25 % requiring expensive and often unsuccessful surgical interventions. The severity of FK and the resultant corneal damage or resolution can be attributed to i) the virulence and bioburden of the fungal pathogen, ii) the host defense mechanism and immune response and iii) sub-optimal diagnostics and anti-fungal treatment strategies. This review provides a comprehensive overview of the multifaceted components that drive FK progression and resolution, highlighting where knowledge gaps exist and areas that warrant further research. ",

author = "Bethany Mills and Naveen Radhakrishnan and {Karthikeyan Rajapandian}, {Siva Ganesa} and Gunasekaran Rameshkumar and Prajna Lalitha and Prajna, {N. Venkatesh}",

year = "2020",

month = nov,

day = "26",

doi = "10.1016/j.exer.2020.108372",

language = "English",

pages = "108372",

journal = "Experimental Eye Research",

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AU - Mills, Bethany

AU - Radhakrishnan, Naveen

AU - Karthikeyan Rajapandian, Siva Ganesa

AU - Rameshkumar, Gunasekaran

AU - Lalitha, Prajna

AU - Prajna, N. Venkatesh

PY - 2020/11/26

Y1 - 2020/11/26

N2 - Fungal keratitis (FK) accounts for approximately half of the microbial keratitis encountered in low middle income countries (LMICs) and predominantly affect the working rural-poor. FK causes significant morbidity with the majority of patients left with moderate or worse visual impairment and approximately 25 % requiring expensive and often unsuccessful surgical interventions. The severity of FK and the resultant corneal damage or resolution can be attributed to i) the virulence and bioburden of the fungal pathogen, ii) the host defense mechanism and immune response and iii) sub-optimal diagnostics and anti-fungal treatment strategies. This review provides a comprehensive overview of the multifaceted components that drive FK progression and resolution, highlighting where knowledge gaps exist and areas that warrant further research.

AB - Fungal keratitis (FK) accounts for approximately half of the microbial keratitis encountered in low middle income countries (LMICs) and predominantly affect the working rural-poor. FK causes significant morbidity with the majority of patients left with moderate or worse visual impairment and approximately 25 % requiring expensive and often unsuccessful surgical interventions. The severity of FK and the resultant corneal damage or resolution can be attributed to i) the virulence and bioburden of the fungal pathogen, ii) the host defense mechanism and immune response and iii) sub-optimal diagnostics and anti-fungal treatment strategies. This review provides a comprehensive overview of the multifaceted components that drive FK progression and resolution, highlighting where knowledge gaps exist and areas that warrant further research.

U2 - 10.1016/j.exer.2020.108372

DO - 10.1016/j.exer.2020.108372

M3 - Article

SN - 0014-4835

SP - 108372

JO - Experimental Eye Research

JF - Experimental Eye Research

ER -

The role of fungi in fungal keratitis

Abstract

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IRC Next Steps Plus: Photonic Pathogen Theranostics - Point-of-care image guided photonic therapy of bacterial and fungal infection?

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