The role of intrinsic, non-adrenergic, non-cholinergic inhibitory nerves in the regulation of distensibility of the guinea-pig colon

J S Davison, G T Pearson

Research output: Contribution to journalArticlepeer-review

Abstract

1. The lengthening responses of segments of distal colon of guinea-pigs to applied weights were measured. 2. Distensibility was reduced by tetrodotoxin and quinidine; increased by atropine and hyoscine, and unaffected by guanethidine and phentolamine. 3. Tension changes produced by controlled stretches were increased by tetrodotoxin. 4. These results suggest that there is a net, inhibitory, non-adrenergic, non-cholinergic influence acting on the muscle during stretch against a background of cholinergic excitatory tone. This inhibitory activity may be activated reflexly by stretch.

Original languageEnglish
Pages (from-to)75-7
Number of pages3
JournalPflügers Archiv European Journal of Physiology
Volume381
Issue number1
Publication statusPublished - Jul 1979

Keywords

  • Animals
  • Atropine
  • Colon
  • Gastrointestinal Motility
  • Guanethidine
  • Guinea Pigs
  • Neural Inhibition
  • Phentolamine
  • Quinidine
  • Scopolamine Hydrobromide
  • Tetrodotoxin

Fingerprint

Dive into the research topics of 'The role of intrinsic, non-adrenergic, non-cholinergic inhibitory nerves in the regulation of distensibility of the guinea-pig colon'. Together they form a unique fingerprint.

Cite this