1. The lengthening responses of segments of distal colon of guinea-pigs to applied weights were measured. 2. Distensibility was reduced by tetrodotoxin and quinidine; increased by atropine and hyoscine, and unaffected by guanethidine and phentolamine. 3. Tension changes produced by controlled stretches were increased by tetrodotoxin. 4. These results suggest that there is a net, inhibitory, non-adrenergic, non-cholinergic influence acting on the muscle during stretch against a background of cholinergic excitatory tone. This inhibitory activity may be activated reflexly by stretch.
|Number of pages||3|
|Journal||Pflügers Archiv European Journal of Physiology|
|Publication status||Published - Jul 1979|
- Gastrointestinal Motility
- Guinea Pigs
- Neural Inhibition
- Scopolamine Hydrobromide