Abstract / Description of output
1. The lengthening responses of segments of distal colon of guinea-pigs to applied weights were measured. 2. Distensibility was reduced by tetrodotoxin and quinidine; increased by atropine and hyoscine, and unaffected by guanethidine and phentolamine. 3. Tension changes produced by controlled stretches were increased by tetrodotoxin. 4. These results suggest that there is a net, inhibitory, non-adrenergic, non-cholinergic influence acting on the muscle during stretch against a background of cholinergic excitatory tone. This inhibitory activity may be activated reflexly by stretch.
Original language | English |
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Pages (from-to) | 75-7 |
Number of pages | 3 |
Journal | Pflügers Archiv European Journal of Physiology |
Volume | 381 |
Issue number | 1 |
Publication status | Published - Jul 1979 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Atropine
- Colon
- Gastrointestinal Motility
- Guanethidine
- Guinea Pigs
- Neural Inhibition
- Phentolamine
- Quinidine
- Scopolamine Hydrobromide
- Tetrodotoxin