The role of macrophages in healing the wounded lung

Andreas Alber, Sarah Howie, William Wallace, Nikhil Hirani

Research output: Contribution to journalArticlepeer-review

Abstract

Acute tissue injury is often considered in the context of a wound. The host response to wounding is an orchestrated series of events, the fundamentals of which are preserved across all multicellular organisms. In the human lung, there are a myriad of causes of injury, but only a limited number of consequences: complete resolution, persistent and/or overwhelming inflammation, a combination of resolution/remodelling with fibrosis or progressive fibrosis. In all cases where complete resolution does not occur, there is the potential for significant ongoing morbidity and ultimately death through respiratory failure. In this review, we consider the elements of injury, resolution and repair as they occur in the lung. We specifically focus on the role of the macrophage, long considered to have a pivotal role in regulating the host response to injury and tissue repair.
Original languageEnglish
Pages (from-to)243-251
Number of pages9
JournalInternational Journal of Experimental Pathology
Volume93
Issue number4
DOIs
Publication statusPublished - 1 Aug 2012

Keywords

  • Airway Remodeling/physiology
  • Animals
  • Humans
  • Lung Diseases/etiology
  • Lung Diseases/physiopathology
  • Lung Injury/complications
  • Lung Injury/physiopathology
  • Macrophages, Alveolar/physiology
  • Models, Animal
  • Phenotype
  • Wound Healing/physiology

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