The role of macrophages in influenza A virus infection

Marlynne Q. Nicol, Bernadette M. Dutia*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The importance of macrophages in the control of infections has long been documented, but macrophages have also been shown to contribute to severe influenza A virus infections. Macrophage function ranges from highly proinflammatory to wound healing and regulatory and a picture of diverse subsets with considerable plasticity in function and phenotype is emerging. Within the lung three subsets of macrophage populations have been identified: resident alveolar macrophages, interstitial macrophages and exudate-derived macrophages. Here we review model systems and techniques for defining macrophage function in vivo and discuss macrophage infection in vitro. The use of detailed phenotypic approaches and techniques to dissect the role of individual macrophage subsets in vivo promises rapid advances in this area of research.

Original languageEnglish
Pages (from-to)847-862
Number of pages16
JournalFuture virology
Issue number9
Publication statusPublished - 1 Jan 2014


  • alveolar macrophage
  • infection
  • influenza A virus
  • lung
  • macrophage


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