The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover

Matthew Brook; Nicola K Gray

doi:10.1042/BST20120100

The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover

Matthew Brook, Nicola K Gray

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The function of cytoplasmic PABPs [poly(A)-binding proteins] in promoting mRNA translation has been intensively studied. However, PABPs also have less clearly defined functions in mRNA turnover including roles in default deadenylation, a major rate-limiting step in mRNA decay, as well as roles in the regulation of mRNA turnover by cis-acting control elements and in the detection of aberrant mRNA transcripts. In the present paper, we review our current understanding of the complex roles of PABP1 in mRNA turnover, focusing on recent progress in mammals and highlighting some of the major questions that remain to be addressed.

Original language	English
Pages (from-to)	856-64
Number of pages	9
Journal	Biochemical Society Transactions
Volume	40
Issue number	4
DOIs	https://doi.org/10.1042/BST20120100
Publication status	Published - Aug 2012

Keywords / Materials (for Non-textual outputs)

Animals
MicroRNAs
Poly(A)-Binding Proteins
RNA, Messenger

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10.1042/BST20120100

The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover
Copyright © 2012 The Author(s) This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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http://www.biochemsoctrans.org/bst/040/bst0400856.htm

Poly (A)-binding proteins highlighted the importance of regulated mRNA translation and stability in determing a functional materno-fetal interface
Gray, N., Girardi, G. & Norman, J.
MRC
1/04/12 → 30/09/17
Project: Research

Cite this

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abstract = "The function of cytoplasmic PABPs [poly(A)-binding proteins] in promoting mRNA translation has been intensively studied. However, PABPs also have less clearly defined functions in mRNA turnover including roles in default deadenylation, a major rate-limiting step in mRNA decay, as well as roles in the regulation of mRNA turnover by cis-acting control elements and in the detection of aberrant mRNA transcripts. In the present paper, we review our current understanding of the complex roles of PABP1 in mRNA turnover, focusing on recent progress in mammals and highlighting some of the major questions that remain to be addressed.",

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KW - MicroRNAs

KW - Poly(A)-Binding Proteins

KW - RNA, Messenger

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The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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Poly (A)-binding proteins highlighted the importance of regulated mRNA translation and stability in determing a functional materno-fetal interface

Cite this