The role of microRNAs in herpesvirus latency and persistence

Research output: Contribution to journalArticlepeer-review

Abstract

A fundamental aspect of herpesviruses is their ability to establish a life long latent infection within the host. Current research would suggest that small regulatory RNAs called microRNAs play a central role in all three aspects of virus latency and persistence. In this review we will discuss the role of miRNAs in virus persistence and latency, specifically focusing on herpesviruses. We will cover the current knowledge on the role of miRNAs in establishing and maintaining virus latency and promoting survival of infected cells through targeting of both viral and cellular transcripts, highlighting key publications in the field. We will also discuss potential areas of future research and how novel technologies may aid in determining how miRNAs shape virus latency in the context of herpesvirus infections.

Original languageEnglish
Pages (from-to)739-751
JournalJournal of General Virology
Volume96
Issue number4
DOIs
Publication statusPublished - 18 Nov 2014

Fingerprint

Dive into the research topics of 'The role of microRNAs in herpesvirus latency and persistence'. Together they form a unique fingerprint.

Cite this