The role of miRNA in stem cell pluripotency and commitment to the vascular endothelial lineage

Katie White, Nicole M Kane, Graeme Milligan, Andrew H Baker

Research output: Contribution to journalArticlepeer-review

Abstract

Vascular endothelial cells derived from human pluripotent stem cells have substantial potential for the development of novel vascular therapeutics and cell-based therapies for the repair of ischemic damage. To gain maximum benefit from this source of cells, a complete understanding of the changes in gene expression and how they are regulated is required. miRNAs have been demonstrated to play a critical role in controlling stem cell pluripotency and differentiation and are important for mature endothelial cell function. Specific miRNAs that determine stem cell fate have been identified for a number of different cell lineages; however, in the case of differentiation and specification of vascular endothelial cells, this is yet to be fully elucidated.

Original languageEnglish
Pages (from-to)196-207
Number of pages12
JournalMicrocirculation
Volume19
Issue number3
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Endothelial Cells
  • Humans
  • MicroRNAs
  • Models, Biological
  • Neovascularization, Physiologic
  • Pluripotent Stem Cells

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