The Role of Mitochondria in Glioma Pathophysiology

Bartlomiej B. Ordys, Severine Launay, Ruth F. Deighton, James McCulloch, Ian R. Whittle

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

It has long been recognised that malignant tumours favour aerobic glycolysis to generate ATP and contain abnormalities of the intrinsic, mitochondria-dependent, apoptotic pathway, suggesting the involvement of dysfunctional mitochondria in tumour pathophysiology. However, the mechanisms underlying such processes in gliomas are poorly understood. Few recent studies have evaluated mitochondrial ultrastructure and proteomics in the pathophysiology of malignant gliomas. However, aberrant energy metabolism has been reported in gliomas and mitochondrial dysfunction links to glioma apoptotic signalling have been observed. Mitochondrial structural abnormalities and dysfunction in malignant gliomas is a neglected area of research. Definition of abnormalities in mitochondrial proteomics, membrane potential regulation, energy metabolism and intrinsic apoptotic pathway signalling in gliomas may open novel therapeutic opportunities.

Original languageEnglish
Pages (from-to)64-75
Number of pages12
JournalMolecular Neurobiology
Volume42
Issue number1
DOIs
Publication statusPublished - Aug 2010

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