The Role of Nodes and Nodal Assessment in Diagnosis, Treatment and Prediction in ER+, Node-Positive Breast Cancer

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The majority of breast cancers are oestrogen receptor-positive (ER+). In ER+ cancers, oestrogen acts as a disease driver, so these tumours are likely to be susceptible to endocrine therapy (ET). ET works by blocking the hormone’s synthesis or effect. A significant number of patients diagnosed with breast cancer will have the spread of tumour cells into regional lymph nodes either at the time of diagnosis, or as a recurrence some years later. Patients with node-positive disease have a poorer prognosis and can respond less well to ET. The nodal metastases may be genomically similar or, as is becoming more evident, may differ from the primary tumour. However, nodal metastatic disease is often not assessed, and treatment decisions are almost always based on biomarkers evaluated in the primary tumour. This review will summarise the evidence in the field on ER+, node-positive breast cancer, including diagnosis, treatment, prognosis and predictive tools.
Original languageEnglish
Pages (from-to)1476
JournalJournal of personalized medicine
Volume13
Issue number10
DOIs
Publication statusPublished - 8 Oct 2023

Keywords / Materials (for Non-textual outputs)

  • breast cancer
  • Lymph Nodes
  • oestrogen receptor
  • Endocrine therapy
  • recurrence
  • node positive breast cancer
  • metastasis
  • Biomarkers
  • predictive tools
  • prognosis

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