The role of oxidative stress in the cardiovascular actions of particulate air pollution

Mark R. Miller*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Air pollution has been estimated to be responsible for several millions of deaths worldwide per year, the majority of which have been attributed to cardiovascular causes. The particulate matter in air pollution has been shown impair vascular function, increase blood pressure, promote thrombosis and impair fibrinolysis, accelerate the development of atherosclerosis, increase the extent of myocardial ischaemia, and increase susceptibility to myocardial infarction. The pathways underlying these effects are complex and poorly understood; however, particulate-induced oxidative stress repeatedly emerges as a potential mechanism in all of these detrimental cardiovascular actions. The present mini-review will use diesel exhaust as an example of a pollutant rich in combustion-derived nanoparticles, to describe the potential by which oxidative stress could drive the cardiovascular effects of air pollution.

Original languageEnglish
Pages (from-to)1006-1011
Number of pages6
JournalBiochemical Society Transactions
Volume42
DOIs
Publication statusPublished - Aug 2014

Keywords

  • air pollution
  • atherosclerosis
  • cardiovascular
  • diesel exhaust
  • oxidative stress
  • superoxide
  • DIESEL-EXHAUST INHALATION
  • HEART-RATE-VARIABILITY
  • EXTRAPULMONARY TRANSLOCATION
  • VASCULAR DYSFUNCTION
  • ATHEROSCLEROSIS
  • EXPOSURE
  • PARTICLES
  • INCREASES
  • DISEASE
  • MATTER

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