The role of pluripotency gene regulatory network components in mediating transitions between pluripotent cell states

Nicola Festuccia, Rodrigo Osorno, Valerie Wilson, Ian Chambers

Research output: Contribution to journalArticlepeer-review

Abstract

Pluripotency is a property that early embryonic cells possess over a considerable developmental time span. Accordingly, pluripotent cell lines can be established from the pre-implantation or post-implantation mouse embryo as embryonic stem (ES) or epiblast stem (EpiSC) cell lines, respectively. Maintenance of the pluripotent phenotype depends on the function of specific transcription factors (TFs) operating within a pluripotency gene regulatory network (PGRN). As cells move from an ES cell to an EpiSC state, the PGRN changes with expression of some TFs reduced (e.g. Nanog) or eliminated (e.g. Esrrb). Re-expressing such TFs can move cells back to an earlier developmental identity and is being applied to attempt establishment of human cell lines with the properties of mouse ES cells.
Original languageEnglish
Pages (from-to)504-511
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume23
Issue number5
DOIs
Publication statusPublished - Oct 2013

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