The role of Trim25 in development, disease and RNA metabolism

Gregory Heikel, Nila Roy Choudhury, Gracjan Michlewski

Research output: Contribution to journalReview articlepeer-review

Abstract

Trim25 is a member of the tripartite motif family of E3 ubiquitin ligases. It plays major roles in innate immunity and defence against viral infection, control of cell proliferation and migration of cancer cells. Recent work identified Trim25 as being able to bind to RNA and to regulate Lin28a-mediated uridylation of pre-let-7. Here we review the current knowledge of the role of Trim25 in development, disease and RNA metabolism.

Original languageEnglish
Pages (from-to)1045-50
Number of pages6
JournalBiochemical Society Transactions
Volume44
Issue number4
DOIs
Publication statusPublished - 15 Aug 2016

Keywords

  • E3 ubiquitin ligase
  • novel RNA-binding proteins
  • RNA metabolism
  • Trim25

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