The role of Trim25 in development, disease and RNA metabolism

Gregory Heikel; Nila Roy Choudhury; Gracjan Michlewski

doi:10.1042/BST20160077

The role of Trim25 in development, disease and RNA metabolism

Gregory Heikel, Nila Roy Choudhury, Gracjan Michlewski

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

Trim25 is a member of the tripartite motif family of E3 ubiquitin ligases. It plays major roles in innate immunity and defence against viral infection, control of cell proliferation and migration of cancer cells. Recent work identified Trim25 as being able to bind to RNA and to regulate Lin28a-mediated uridylation of pre-let-7. Here we review the current knowledge of the role of Trim25 in development, disease and RNA metabolism.

Original language	English
Pages (from-to)	1045-50
Number of pages	6
Journal	Biochemical Society Transactions
Volume	44
Issue number	4
DOIs	https://doi.org/10.1042/BST20160077
Publication status	Published - 15 Aug 2016

Keywords / Materials (for Non-textual outputs)

E3 ubiquitin ligase
novel RNA-binding proteins
RNA metabolism
Trim25

Access to Document

10.1042/BST20160077

The role of Trim25 AAM Heikel G et al_minireview_final_plus figures
© 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
Accepted author manuscript, 595 KBLicence: All Rights Reserved

Wellcome Trust Four-Year PhD Studentship (Gregory Heikel)
Beggs, J.
UK-based charities
1/10/15 → 31/12/18
Project: Research
Regulation of miRNA Biogenesis and function in humans
Michlewski, G.
MRC
1/01/11 → 31/12/15
Project: Research

Cite this

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title = "The role of Trim25 in development, disease and RNA metabolism",

abstract = "Trim25 is a member of the tripartite motif family of E3 ubiquitin ligases. It plays major roles in innate immunity and defence against viral infection, control of cell proliferation and migration of cancer cells. Recent work identified Trim25 as being able to bind to RNA and to regulate Lin28a-mediated uridylation of pre-let-7. Here we review the current knowledge of the role of Trim25 in development, disease and RNA metabolism.",

keywords = "E3 ubiquitin ligase, novel RNA-binding proteins, RNA metabolism, Trim25",

author = "Gregory Heikel and Choudhury, {Nila Roy} and Gracjan Michlewski",

note = "This is a review. C 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society. Email sent to GM requesting the AAM and the DoA 24/07/2018 EN",

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AU - Heikel, Gregory

AU - Choudhury, Nila Roy

AU - Michlewski, Gracjan

N1 - This is a review. C 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society. Email sent to GM requesting the AAM and the DoA 24/07/2018 EN

PY - 2016/8/15

Y1 - 2016/8/15

N2 - Trim25 is a member of the tripartite motif family of E3 ubiquitin ligases. It plays major roles in innate immunity and defence against viral infection, control of cell proliferation and migration of cancer cells. Recent work identified Trim25 as being able to bind to RNA and to regulate Lin28a-mediated uridylation of pre-let-7. Here we review the current knowledge of the role of Trim25 in development, disease and RNA metabolism.

AB - Trim25 is a member of the tripartite motif family of E3 ubiquitin ligases. It plays major roles in innate immunity and defence against viral infection, control of cell proliferation and migration of cancer cells. Recent work identified Trim25 as being able to bind to RNA and to regulate Lin28a-mediated uridylation of pre-let-7. Here we review the current knowledge of the role of Trim25 in development, disease and RNA metabolism.

KW - E3 ubiquitin ligase

KW - novel RNA-binding proteins

KW - RNA metabolism

KW - Trim25

U2 - 10.1042/BST20160077

DO - 10.1042/BST20160077

M3 - Review article

C2 - 27528750

SN - 0300-5127

VL - 44

SP - 1045

EP - 1050

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 4

ER -

The role of Trim25 in development, disease and RNA metabolism

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

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Projects

Wellcome Trust Four-Year PhD Studentship (Gregory Heikel)

Regulation of miRNA Biogenesis and function in humans

Cite this