The roles of cytoplasmic poly(A)-binding proteins in regulating gene expression: a developmental perspective

Barbara Gorgoni, Nicola K Gray

Research output: Contribution to journalArticlepeer-review

Abstract

Poly(A)-binding proteins (PABPs) are central to the regulation of messenger RNA (mRNA) translation and stability; however, the roles and contributions of different PABP family members in controlling gene expression are not yet fully understood. In this paper, the current state of knowledge of the different cytoplasmic PABP proteins and their function in animal cells will be summarised, with particular reference to their roles in development. Possible regulatory mechanisms and potential new roles for these proteins in the control of specific mRNAs are also highlighted.
Original languageEnglish
Pages (from-to)125-41
Number of pages17
JournalBriefings in functional genomics & proteomics
Volume3
Issue number2
Publication statusPublished - 2004

Fingerprint

Dive into the research topics of 'The roles of cytoplasmic poly(A)-binding proteins in regulating gene expression: a developmental perspective'. Together they form a unique fingerprint.

Cite this