The route to identification of immunological correlates of protection in ruminants

Gary Entrican, C. J. McInnes, S. R. Wattegedera, Jayne Hope, Yolanda Corripio-Miyar, Y. Pang, Elizabeth Glass

Research output: Contribution to conferenceAbstract


The strategic development of safe and effective vaccines is dependent on the identification of correlates of protection and reproducing these with suitable pathogen antigens delivered in an appropriate manner. Optimal efficacy is achieved by initiating immune responses by targeting the components of the innate immune system that then direct and modulate the adaptive immune response in a manner that generates long-lasting immunological memory to protect against the pathogen in question. For vaccine design it is important that neither the pathogen components, nor the adjuvant used to deliver them, cause inappropriate inflammation or induce ineffective immune responses. Measurement of the immunological correlates of protection in any given species is dependent on reagents and assays that define immune function. We have recently initiated a new Industrial Partnership collaborative project between Moredun Research Institute and the Roslin Institute at University of Edinburgh to improve our capability of studying myeloid-lymphoid cell interactions in cattle and sheep. This project is funded by BBSRC/RESAS and AbD Serotec. The specific aims are to define monocytes/macrophage subsets and CD4+ve Thelper cell subsets based on expression of cell surface molecules, cytokine profiles and intracellular transcription factors. This will ultimately inform on mechanisms to target specific immune responses in ruminants through vaccination. The reagents developed and evaluated by this project will be made available to the research community through rapid commercialisation.
Original languageEnglish
Publication statusUnpublished - 2012
Event4th European Veterinary Immunology Workshop - Edinburgh
Duration: 2 Sep 20124 Sep 2012


Conference4th European Veterinary Immunology Workshop


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