The Ruminant Telomere-to-Telomere (RT2T) Consortium

Theodore S Kalbfleisch; Stephanie D McKay; Brenda M Murdoch; David L Adelson; Diego Almansa-Villa; Gabrielle Becker; Linda M Beckett; María José Benítez-Galeano; Fernando Biase; Theresa Casey; Edward Chuong; Emily Clark; Shannon Clarke; Noelle Cockett; Christine Couldrey; Brian W Davis; Christine G Elsik; Thomas Faraut; Yahui Gao; Carine Genet; Patrick Grady; Jonathan Green; Richard Green; Dailu Guan; Darren Hagen; Gabrielle A Hartley; Mike Heaton; Savannah J Hoyt; Wen Huang; Erich Jarvis; Jenna Kalleberg; Hasan Khatib; Klaus-Peter Koepfi; James Koltes; Sergey Koren; Christa Kuehn; Tosso Leeb; Alexander Leonard; George E Liu; Wai Yee Low; Hunter McConnell; Kathryn McRae; Karen Miga; Michelle Mousel; Holly Neibergs; Temitayo Olagunju; Matt Pennell; Bruna Petry; Mirjam Pewsner; Adam M Phillippy; Brandon D Pickett; Paulene Pineda; Tamara Potapova; Satyanarayana Rachagani; Arang Rhie; Monique Rijnkels; Annie Robic; Nelida Rodriguez Osorio; Yana Safonova; Gustavo Schettini; Robert D Schnabel; Nagabhishek Sirpu Natesh; Morgan Stegemiller; Jessica Storer; Paul Stothard; Caleb Stull; Gwenola Tosser-Klopp; Germán M Traglia; Christopher K Tuggle; Curtis P Van Tassell; Corey Watson; Rosemarie Weikard; Klaus Wimmers; Shangqian Xie; Liu Yang; Timothy P L Smith; Rachel J O'Neill; Benjamin D Rosen

doi:10.1038/s41588-024-01835-2

The Ruminant Telomere-to-Telomere (RT2T) Consortium

Theodore S Kalbfleisch, Stephanie D McKay, Brenda M Murdoch, David L Adelson, Diego Almansa-Villa, Gabrielle Becker, Linda M Beckett, María José Benítez-Galeano, Fernando Biase, Theresa Casey, Edward Chuong, Emily Clark, Shannon Clarke, Noelle Cockett, Christine Couldrey, Brian W Davis, Christine G Elsik, Thomas Faraut, Yahui Gao, Carine GenetPatrick Grady, Jonathan Green, Richard Green, Dailu Guan, Darren Hagen, Gabrielle A Hartley, Mike Heaton, Savannah J Hoyt, Wen Huang, Erich Jarvis, Jenna Kalleberg, Hasan Khatib, Klaus-Peter Koepfi, James Koltes, Sergey Koren, Christa Kuehn, Tosso Leeb, Alexander Leonard, George E Liu, Wai Yee Low, Hunter McConnell, Kathryn McRae, Karen Miga, Michelle Mousel, Holly Neibergs, Temitayo Olagunju, Matt Pennell, Bruna Petry, Mirjam Pewsner, Adam M Phillippy, Brandon D Pickett, Paulene Pineda, Tamara Potapova, Satyanarayana Rachagani, Arang Rhie, Monique Rijnkels, Annie Robic, Nelida Rodriguez Osorio, Yana Safonova, Gustavo Schettini, Robert D Schnabel, Nagabhishek Sirpu Natesh, Morgan Stegemiller, Jessica Storer, Paul Stothard, Caleb Stull, Gwenola Tosser-Klopp, Germán M Traglia, Christopher K Tuggle, Curtis P Van Tassell, Corey Watson, Rosemarie Weikard, Klaus Wimmers, Shangqian Xie, Liu Yang, Timothy P L Smith, Rachel J O'Neill, Benjamin D Rosen

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

Telomere-to-telomere (T2T) assemblies reveal new insights into the structure and function of the previously 'invisible' parts of the genome and allow comparative analyses of complete genomes across entire clades. We present here an open collaborative effort, termed the 'Ruminant T2T Consortium' (RT2T), that aims to generate complete diploid assemblies for numerous species of the Artiodactyla suborder Ruminantia to examine chromosomal evolution in the context of natural selection and domestication of species used as livestock.

Original language	English
Pages (from-to)	1566-1573
Number of pages	18
Journal	Nature Genetics
Volume	56
Issue number	8
Early online date	5 Aug 2024
DOIs	https://doi.org/10.1038/s41588-024-01835-2
Publication status	Published - Aug 2024

Keywords / Materials (for Non-textual outputs)

Animals
Diploidy
Evolution, Molecular
Genome/genetics
Phylogeny
Ruminants/genetics
Selection, Genetic
Telomere/genetics

Access to Document

10.1038/s41588-024-01835-2

FinalClean (003)Accepted author manuscript, 301 KBLicence: Creative Commons: Attribution (CC-BY)

Identifying the genomic basis of complex traits in farmed animals
Headon, D.
1/04/23 → 31/03/28
Project: Research
ISP 1 2023/28 Genes & Traits for Healthy Animals
Headon, D.
1/04/23 → 31/03/28
Project: Research

Cite this

Kalbfleisch, T. S., McKay, S. D., Murdoch, B. M., Adelson, D. L., Almansa-Villa, D., Becker, G., Beckett, L. M., Benítez-Galeano, M. J., Biase, F., Casey, T., Chuong, E., Clark, E., Clarke, S., Cockett, N., Couldrey, C., Davis, B. W., Elsik, C. G., Faraut, T., Gao, Y., ... Rosen, B. D. (2024). The Ruminant Telomere-to-Telomere (RT2T) Consortium. Nature Genetics, 56(8), 1566-1573. https://doi.org/10.1038/s41588-024-01835-2

@article{fb24791d1c9643f08e2b09b6a1647fef,

title = "The Ruminant Telomere-to-Telomere (RT2T) Consortium",

abstract = "Telomere-to-telomere (T2T) assemblies reveal new insights into the structure and function of the previously 'invisible' parts of the genome and allow comparative analyses of complete genomes across entire clades. We present here an open collaborative effort, termed the 'Ruminant T2T Consortium' (RT2T), that aims to generate complete diploid assemblies for numerous species of the Artiodactyla suborder Ruminantia to examine chromosomal evolution in the context of natural selection and domestication of species used as livestock.",

keywords = "Animals, Diploidy, Evolution, Molecular, Genome/genetics, Phylogeny, Ruminants/genetics, Selection, Genetic, Telomere/genetics",

author = "Kalbfleisch, {Theodore S} and McKay, {Stephanie D} and Murdoch, {Brenda M} and Adelson, {David L} and Diego Almansa-Villa and Gabrielle Becker and Beckett, {Linda M} and Ben{\'i}tez-Galeano, {Mar{\'i}a Jos{\'e}} and Fernando Biase and Theresa Casey and Edward Chuong and Emily Clark and Shannon Clarke and Noelle Cockett and Christine Couldrey and Davis, {Brian W} and Elsik, {Christine G} and Thomas Faraut and Yahui Gao and Carine Genet and Patrick Grady and Jonathan Green and Richard Green and Dailu Guan and Darren Hagen and Hartley, {Gabrielle A} and Mike Heaton and Hoyt, {Savannah J} and Wen Huang and Erich Jarvis and Jenna Kalleberg and Hasan Khatib and Klaus-Peter Koepfi and James Koltes and Sergey Koren and Christa Kuehn and Tosso Leeb and Alexander Leonard and Liu, {George E} and Low, {Wai Yee} and Hunter McConnell and Kathryn McRae and Karen Miga and Michelle Mousel and Holly Neibergs and Temitayo Olagunju and Matt Pennell and Bruna Petry and Mirjam Pewsner and Phillippy, {Adam M} and Pickett, {Brandon D} and Paulene Pineda and Tamara Potapova and Satyanarayana Rachagani and Arang Rhie and Monique Rijnkels and Annie Robic and {Rodriguez Osorio}, Nelida and Yana Safonova and Gustavo Schettini and Schnabel, {Robert D} and {Sirpu Natesh}, Nagabhishek and Morgan Stegemiller and Jessica Storer and Paul Stothard and Caleb Stull and Gwenola Tosser-Klopp and Traglia, {Germ{\'a}n M} and Tuggle, {Christopher K} and {Van Tassell}, {Curtis P} and Corey Watson and Rosemarie Weikard and Klaus Wimmers and Shangqian Xie and Liu Yang and Smith, {Timothy P L} and O'Neill, {Rachel J} and Rosen, {Benjamin D}",

note = "{\textcopyright} 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.",

year = "2024",

month = aug,

doi = "10.1038/s41588-024-01835-2",

language = "English",

volume = "56",

pages = "1566--1573",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

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Kalbfleisch, TS, McKay, SD, Murdoch, BM, Adelson, DL, Almansa-Villa, D, Becker, G, Beckett, LM, Benítez-Galeano, MJ, Biase, F, Casey, T, Chuong, E, Clark, E, Clarke, S, Cockett, N, Couldrey, C, Davis, BW, Elsik, CG, Faraut, T, Gao, Y, Genet, C, Grady, P, Green, J, Green, R, Guan, D, Hagen, D, Hartley, GA, Heaton, M, Hoyt, SJ, Huang, W, Jarvis, E, Kalleberg, J, Khatib, H, Koepfi, K-P, Koltes, J, Koren, S, Kuehn, C, Leeb, T, Leonard, A, Liu, GE, Low, WY, McConnell, H, McRae, K, Miga, K, Mousel, M, Neibergs, H, Olagunju, T, Pennell, M, Petry, B, Pewsner, M, Phillippy, AM, Pickett, BD, Pineda, P, Potapova, T, Rachagani, S, Rhie, A, Rijnkels, M, Robic, A, Rodriguez Osorio, N, Safonova, Y, Schettini, G, Schnabel, RD, Sirpu Natesh, N, Stegemiller, M, Storer, J, Stothard, P, Stull, C, Tosser-Klopp, G, Traglia, GM, Tuggle, CK, Van Tassell, CP, Watson, C, Weikard, R, Wimmers, K, Xie, S, Yang, L, Smith, TPL, O'Neill, RJ & Rosen, BD 2024, 'The Ruminant Telomere-to-Telomere (RT2T) Consortium', Nature Genetics, vol. 56, no. 8, pp. 1566-1573. https://doi.org/10.1038/s41588-024-01835-2

TY - JOUR

T1 - The Ruminant Telomere-to-Telomere (RT2T) Consortium

AU - Kalbfleisch, Theodore S

AU - McKay, Stephanie D

AU - Murdoch, Brenda M

AU - Adelson, David L

AU - Almansa-Villa, Diego

AU - Becker, Gabrielle

AU - Beckett, Linda M

AU - Benítez-Galeano, María José

AU - Biase, Fernando

AU - Casey, Theresa

AU - Chuong, Edward

AU - Clark, Emily

AU - Clarke, Shannon

AU - Cockett, Noelle

AU - Couldrey, Christine

AU - Davis, Brian W

AU - Elsik, Christine G

AU - Faraut, Thomas

AU - Gao, Yahui

AU - Genet, Carine

AU - Grady, Patrick

AU - Green, Jonathan

AU - Green, Richard

AU - Guan, Dailu

AU - Hagen, Darren

AU - Hartley, Gabrielle A

AU - Heaton, Mike

AU - Hoyt, Savannah J

AU - Huang, Wen

AU - Jarvis, Erich

AU - Kalleberg, Jenna

AU - Khatib, Hasan

AU - Koepfi, Klaus-Peter

AU - Koltes, James

AU - Koren, Sergey

AU - Kuehn, Christa

AU - Leeb, Tosso

AU - Leonard, Alexander

AU - Liu, George E

AU - Low, Wai Yee

AU - McConnell, Hunter

AU - McRae, Kathryn

AU - Miga, Karen

AU - Mousel, Michelle

AU - Neibergs, Holly

AU - Olagunju, Temitayo

AU - Pennell, Matt

AU - Petry, Bruna

AU - Pewsner, Mirjam

AU - Phillippy, Adam M

AU - Pickett, Brandon D

AU - Pineda, Paulene

AU - Potapova, Tamara

AU - Rachagani, Satyanarayana

AU - Rhie, Arang

AU - Rijnkels, Monique

AU - Robic, Annie

AU - Rodriguez Osorio, Nelida

AU - Safonova, Yana

AU - Schettini, Gustavo

AU - Schnabel, Robert D

AU - Sirpu Natesh, Nagabhishek

AU - Stegemiller, Morgan

AU - Storer, Jessica

AU - Stothard, Paul

AU - Stull, Caleb

AU - Tosser-Klopp, Gwenola

AU - Traglia, Germán M

AU - Tuggle, Christopher K

AU - Van Tassell, Curtis P

AU - Watson, Corey

AU - Weikard, Rosemarie

AU - Wimmers, Klaus

AU - Xie, Shangqian

AU - Yang, Liu

AU - Smith, Timothy P L

AU - O'Neill, Rachel J

AU - Rosen, Benjamin D

PY - 2024/8

Y1 - 2024/8

N2 - Telomere-to-telomere (T2T) assemblies reveal new insights into the structure and function of the previously 'invisible' parts of the genome and allow comparative analyses of complete genomes across entire clades. We present here an open collaborative effort, termed the 'Ruminant T2T Consortium' (RT2T), that aims to generate complete diploid assemblies for numerous species of the Artiodactyla suborder Ruminantia to examine chromosomal evolution in the context of natural selection and domestication of species used as livestock.

AB - Telomere-to-telomere (T2T) assemblies reveal new insights into the structure and function of the previously 'invisible' parts of the genome and allow comparative analyses of complete genomes across entire clades. We present here an open collaborative effort, termed the 'Ruminant T2T Consortium' (RT2T), that aims to generate complete diploid assemblies for numerous species of the Artiodactyla suborder Ruminantia to examine chromosomal evolution in the context of natural selection and domestication of species used as livestock.

KW - Animals

KW - Diploidy

KW - Evolution, Molecular

KW - Genome/genetics

KW - Phylogeny

KW - Ruminants/genetics

KW - Selection, Genetic

KW - Telomere/genetics

U2 - 10.1038/s41588-024-01835-2

DO - 10.1038/s41588-024-01835-2

M3 - Review article

C2 - 39103649

SN - 1061-4036

VL - 56

SP - 1566

EP - 1573

JO - Nature Genetics

JF - Nature Genetics

IS - 8

ER -

The Ruminant Telomere-to-Telomere (RT2T) Consortium

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Projects

Identifying the genomic basis of complex traits in farmed animals

ISP 1 2023/28 Genes & Traits for Healthy Animals

Cite this