The silicon trypanosome

Barbara M. Bakker, R. Luise Krauth-Siegel, Christine Clayton, Keith Matthews, Mark Girolami, Hans V. Westerhoff, Paul A. M. Michels, Rainer Breitling, Michael P. Barrett

Research output: Contribution to journalArticlepeer-review

Abstract

African trypanosomes have emerged as promising unicellular model organisms for the next generation of systems biology. They offer unique advantages, due to their relative simplicity, the availability of all standard genomics techniques and a long history of quantitative research. Reproducible cultivation methods exist for morphologically and physiologically distinct life-cycle stages. The genome has been sequenced, and microarrays, RNA-interference and high-accuracy metabolomics are available. Furthermore, the availability of extensive kinetic data on all glycolytic enzymes has led to the early development of a complete, experiment-based dynamic model of an important biochemical pathway. Here we describe the achievements of trypanosome systems biology so far and outline the necessary steps towards the ambitious aim of creating a 'Silicon Trypanosome', a comprehensive, experiment-based, multi-scale mathematical model of trypanosome physiology. We expect that, in the long run, the quantitative modelling enabled by the Silicon Trypanosome will play a key role in selecting the most suitable targets for developing new anti-parasite drugs.

Original languageEnglish
Pages (from-to)1333-1341
Number of pages9
JournalParasitology
Volume137
Issue number9
DOIs
Publication statusPublished - Aug 2010

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