The spatial arrangements of stochastic Ca2+ signals triggered by IP3 release

Svitlana Braichenko, Atul Bhaskar, Srinandan Dasmahapatra

Research output: Contribution to conferencePosterpeer-review

Abstract

Clusters of IP3 receptor channels in the membranes of the endoplasmic reticulum (ER) of many non-excitable cells release calcium ions in a cooperative manner giving rise to dynamical patterns such as Ca2+ puffs, waves and oscillations that occur on various spatial and temporal scales. We introduce a stochastic reaction-diffusion model of randomly distributed IP3 receptors using a principled reduction of a detailed Markov chain description of individual channels. Our model reveals how the crucial characteristic of cell regulation such as inter-wave intervals (IWI) depends on the IP3 loads. Furthermore, by performing a correlation analysis of the [Ca2+] at the neighbouring clusters, we obtain the principal characteristics of the membrane which define the possibility of Ca2+ wave initiation and propagation.
Original languageEnglish
Publication statusPublished - 9 May 2018
Event3rd European Calcium Channel Conference - Alpbach, Austria
Duration: 9 May 201812 May 2018
https://www.uibk.ac.at/pharmazie/pharmakologie/eccc/index.html.en

Conference

Conference3rd European Calcium Channel Conference
Country/TerritoryAustria
CityAlpbach
Period9/05/1812/05/18
Internet address

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