Clusters of IP3 receptor channels in the membranes of the endoplasmic reticulum (ER) of many non-excitable cells release calcium ions in a cooperative manner giving rise to dynamical patterns such as Ca2+ puffs, waves and oscillations that occur on various spatial and temporal scales. We introduce a stochastic reaction-diffusion model of randomly distributed IP3 receptors using a principled reduction of a detailed Markov chain description of individual channels. Our model reveals how the crucial characteristic of cell regulation such as inter-wave intervals (IWI) depends on the IP3 loads. Furthermore, by performing a correlation analysis of the [Ca2+] at the neighbouring clusters, we obtain the principal characteristics of the membrane which define the possibility of Ca2+ wave initiation and propagation.
|Publication status||Published - 9 May 2018|
|Event||3rd European Calcium Channel Conference - Alpbach, Austria|
Duration: 9 May 2018 → 12 May 2018
|Conference||3rd European Calcium Channel Conference|
|Period||9/05/18 → 12/05/18|