The spatial organization of the human genome

Research output: Contribution to journalArticlepeer-review

Abstract

In vivo, the human genome functions as a complex, folded, three-dimensional chromatin polymer. Understanding how the human genome is spatially organized and folded inside the cell nucleus is therefore central to understanding how genes are regulated in normal development and dysregulated in disease. Established light microscopy-based approaches and more recent molecular chromosome conformation capture methods are now combining to give us unprecedented insight into this fascinating aspect of human genomics.
Original languageEnglish
Pages (from-to)67-84
Number of pages18
JournalAnnual review of genomics and human genetics
Volume14
DOIs
Publication statusPublished - 2013

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