The spindle checkpoint: Structural insights into dynamic signalling

Andrea Musacchio; Kevin G Hardwick

doi:10.1038/nrm929

The spindle checkpoint: Structural insights into dynamic signalling

Andrea Musacchio, Kevin G Hardwick

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Chromosome segregation is a complex and astonishingly accurate process whose inner working is beginning to be understood at the molecular level. The spindle checkpoint plays a key role in ensuring the fidelity of this process. It monitors the interactions between chromosomes and microtubules, and delays mitotic progression to allow extra time to correct defects. Here, we review and integrate findings on the dynamics of checkpoint proteins at kinetochores with structural information about signalling complexes.

Original language	English
Pages (from-to)	731-741
Number of pages	11
Journal	Nature reviews Molecular cell biology
Volume	3
Issue number	10
DOIs	https://doi.org/10.1038/nrm929
Publication status	Published - 1 Oct 2002

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10.1038/nrm929

Analysis of mitosis and spindle check point in yeast and frogs
Hardwick, K.
UK-based charities
1/10/00 → 31/05/08
Project: Research

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title = "The spindle checkpoint: Structural insights into dynamic signalling",

abstract = "Chromosome segregation is a complex and astonishingly accurate process whose inner working is beginning to be understood at the molecular level. The spindle checkpoint plays a key role in ensuring the fidelity of this process. It monitors the interactions between chromosomes and microtubules, and delays mitotic progression to allow extra time to correct defects. Here, we review and integrate findings on the dynamics of checkpoint proteins at kinetochores with structural information about signalling complexes.",

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AB - Chromosome segregation is a complex and astonishingly accurate process whose inner working is beginning to be understood at the molecular level. The spindle checkpoint plays a key role in ensuring the fidelity of this process. It monitors the interactions between chromosomes and microtubules, and delays mitotic progression to allow extra time to correct defects. Here, we review and integrate findings on the dynamics of checkpoint proteins at kinetochores with structural information about signalling complexes.

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DO - 10.1038/nrm929

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JO - Nature reviews Molecular cell biology

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IS - 10

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The spindle checkpoint: Structural insights into dynamic signalling

Abstract / Description of output

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Projects

Analysis of mitosis and spindle check point in yeast and frogs

Cite this