The StpA protein functions as a molecular adapter to mediate repression of the bgl operon by truncated H-NS in Escherichia coli

A Free; R M Williams; C J Dorman

The StpA protein functions as a molecular adapter to mediate repression of the bgl operon by truncated H-NS in Escherichia coli

A Free, R M Williams, C J Dorman

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The mechanism of repression of the beta-glucoside utilization (bgl) operon of Escherichia coli by a carboxy-terminally truncated derivative of the nucleoid-associated protein H-NS which is defective in DNA binding was investigated. The DNA-binding function of the H-NS-like protein StpA was found to be necessary for repression, which is consistent with a role for StpA as a DNA-binding adapter for mutant derivatives of H-NS.

Original language	English
Pages (from-to)	994-7
Number of pages	4
Journal	Journal of Bacteriology
Volume	180
Issue number	4
Publication status	Published - Feb 1998

Keywords / Materials (for Non-textual outputs)

Amino Acid Transport Systems
Bacterial Proteins
Carrier Proteins
DNA-Binding Proteins
Enzyme Repression
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Genes, Reporter
Glucosides
Molecular Chaperones
Mutation
Operon
Peptide Fragments
Sequence Deletion

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http://jb.asm.org/content/180/4/994.long

Cite this

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title = "The StpA protein functions as a molecular adapter to mediate repression of the bgl operon by truncated H-NS in Escherichia coli",

abstract = "The mechanism of repression of the beta-glucoside utilization (bgl) operon of Escherichia coli by a carboxy-terminally truncated derivative of the nucleoid-associated protein H-NS which is defective in DNA binding was investigated. The DNA-binding function of the H-NS-like protein StpA was found to be necessary for repression, which is consistent with a role for StpA as a DNA-binding adapter for mutant derivatives of H-NS.",

keywords = "Amino Acid Transport Systems, Bacterial Proteins, Carrier Proteins, DNA-Binding Proteins, Enzyme Repression, Escherichia coli, Escherichia coli Proteins, Gene Expression Regulation, Bacterial, Genes, Reporter, Glucosides, Molecular Chaperones, Mutation, Operon, Peptide Fragments, Sequence Deletion",

author = "A Free and Williams, {R M} and Dorman, {C J}",

year = "1998",

month = feb,

language = "English",

volume = "180",

pages = "994--7",

journal = "Journal of Bacteriology",

issn = "0021-9193",

publisher = "American Society for Microbiology",

number = "4",

}

TY - JOUR

T1 - The StpA protein functions as a molecular adapter to mediate repression of the bgl operon by truncated H-NS in Escherichia coli

AU - Free, A

AU - Williams, R M

AU - Dorman, C J

PY - 1998/2

Y1 - 1998/2

N2 - The mechanism of repression of the beta-glucoside utilization (bgl) operon of Escherichia coli by a carboxy-terminally truncated derivative of the nucleoid-associated protein H-NS which is defective in DNA binding was investigated. The DNA-binding function of the H-NS-like protein StpA was found to be necessary for repression, which is consistent with a role for StpA as a DNA-binding adapter for mutant derivatives of H-NS.

AB - The mechanism of repression of the beta-glucoside utilization (bgl) operon of Escherichia coli by a carboxy-terminally truncated derivative of the nucleoid-associated protein H-NS which is defective in DNA binding was investigated. The DNA-binding function of the H-NS-like protein StpA was found to be necessary for repression, which is consistent with a role for StpA as a DNA-binding adapter for mutant derivatives of H-NS.

KW - Amino Acid Transport Systems

KW - Bacterial Proteins

KW - Carrier Proteins

KW - DNA-Binding Proteins

KW - Enzyme Repression

KW - Escherichia coli

KW - Escherichia coli Proteins

KW - Gene Expression Regulation, Bacterial

KW - Genes, Reporter

KW - Glucosides

KW - Molecular Chaperones

KW - Mutation

KW - Operon

KW - Peptide Fragments

KW - Sequence Deletion

M3 - Article

C2 - 9473058

SN - 0021-9193

VL - 180

SP - 994

EP - 997

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 4

ER -

The StpA protein functions as a molecular adapter to mediate repression of the bgl operon by truncated H-NS in Escherichia coli

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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