The STR/ort mouse model of spontaneous osteoarthritis – an update

Katherine Staines; Blandine Poulet; Diorbhail N. Wentworth; Andrew A. Pitsillides

doi:10.1016/j.joca.2016.12.014

The STR/ort mouse model of spontaneous osteoarthritis – an update

Katherine Staines, Blandine Poulet, Diorbhail N. Wentworth, Andrew A. Pitsillides

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. Mouse models of osteoarthritis are proving critical in advancing our understanding of the underpinning molecular mechanisms. The STR/ort mouse is a well-recognized model which develops a natural form of osteoarthritis very similar to the human disease. In this Review we discuss the use of the STR/ort mouse in understanding this multifactorial disease with an emphasis on recent advances in its genetics and its bone, endochondral and immune phenotypes.

Original language	English
Pages (from-to)	802-808
Journal	Osteoarthritis and Cartilage
Volume	25
Issue number	6
Early online date	11 Dec 2016
DOIs	https://doi.org/10.1016/j.joca.2016.12.014
Publication status	Published - Jun 2017

Keywords / Materials (for Non-textual outputs)

STR/ort
osteoarthritis
articular cartilage
subchondral bone

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10.1016/j.joca.2016.12.014

The STR/ort mouse model of spontaneous osteoarthritis – an updateAccepted author manuscript, 178 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

Subchondral bone sclerosis in OA is driven by defective mineralisation and osteocyte formation
Farquharson, C. (Principal Investigator)
UK-based charities
1/01/14 → 31/12/16
Project: Research

Cite this

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title = "The STR/ort mouse model of spontaneous osteoarthritis – an update",

abstract = "Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. Mouse models of osteoarthritis are proving critical in advancing our understanding of the underpinning molecular mechanisms. The STR/ort mouse is a well-recognized model which develops a natural form of osteoarthritis very similar to the human disease. In this Review we discuss the use of the STR/ort mouse in understanding this multifactorial disease with an emphasis on recent advances in its genetics and its bone, endochondral and immune phenotypes. ",

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AU - Poulet, Blandine

AU - Wentworth, Diorbhail N.

AU - Pitsillides, Andrew A.

PY - 2017/6

Y1 - 2017/6

N2 - Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. Mouse models of osteoarthritis are proving critical in advancing our understanding of the underpinning molecular mechanisms. The STR/ort mouse is a well-recognized model which develops a natural form of osteoarthritis very similar to the human disease. In this Review we discuss the use of the STR/ort mouse in understanding this multifactorial disease with an emphasis on recent advances in its genetics and its bone, endochondral and immune phenotypes.

AB - Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. Mouse models of osteoarthritis are proving critical in advancing our understanding of the underpinning molecular mechanisms. The STR/ort mouse is a well-recognized model which develops a natural form of osteoarthritis very similar to the human disease. In this Review we discuss the use of the STR/ort mouse in understanding this multifactorial disease with an emphasis on recent advances in its genetics and its bone, endochondral and immune phenotypes.

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KW - osteoarthritis

KW - articular cartilage

KW - subchondral bone

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DO - 10.1016/j.joca.2016.12.014

M3 - Article

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VL - 25

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EP - 808

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

IS - 6

ER -

The STR/ort mouse model of spontaneous osteoarthritis – an update

Abstract

Keywords / Materials (for Non-textual outputs)

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Subchondral bone sclerosis in OA is driven by defective mineralisation and osteocyte formation

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