The STR/ort mouse model of spontaneous osteoarthritis – an update

Katherine Staines, Blandine Poulet, Diorbhail N. Wentworth, Andrew A. Pitsillides

Research output: Contribution to journalArticlepeer-review

Abstract

Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. Mouse models of osteoarthritis are proving critical in advancing our understanding of the underpinning molecular mechanisms. The STR/ort mouse is a well-recognized model which develops a natural form of osteoarthritis very similar to the human disease. In this Review we discuss the use of the STR/ort mouse in understanding this multifactorial disease with an emphasis on recent advances in its genetics and its bone, endochondral and immune phenotypes.
Original languageEnglish
Pages (from-to)802-808
JournalOsteoarthritis and Cartilage
Volume25
Issue number6
Early online date11 Dec 2016
DOIs
Publication statusPublished - Jun 2017

Keywords

  • STR/ort
  • osteoarthritis
  • articular cartilage
  • subchondral bone

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