The Synergy of Electrospinning and Imprinting for Faithful Replication of Fiber Structures

Gozde Sahin, Erik Vrij, Rhiannon Grant*, Stefan Giselbrecht*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Electrospinning is a powerful method to fabricate structures resembling the fibrous texture of the native extracellular matrix. However, the random fiber deposition of the process hinders a faithful reproduction of the fiber mesh morphology on multiple samples, which raises difficulties in experimental designs to systematically test and assess cell response in vitro. A multi-replication process to precisely reproduce the fiber morphology on different cell culture substrates is developed. The process involves a decoupling of the fiber structure, material, and porosity by combining the key advantages of electrospinning and imprinting. With this, fiber patterns having a diameter between 0.4 and 2.8 µm are replicated on polycarbonate, polystyrene, poly(methyl methacrylate), and cyclic olefin copolymer films. Identical fiber morphology is, then, obtained on porous films having a pore diameter between 2 and 12 µm. Having full control over these parameters allows the multireplication process to engineer well-characterized cell microenvironments, which can potentially be used to further investigate complex cell–material interactions.

Original languageEnglish
Article number2300344
JournalAdvanced Materials Technologies
Issue number16
Early online date4 Jul 2023
Publication statusPublished - 25 Aug 2023

Keywords / Materials (for Non-textual outputs)

  • cell microenvironments
  • electrospinning
  • imprinting
  • nanotechnology


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