The systems biology simulation core algorithm

Roland Keller, Alexander Dörr, Akito Tabira, Akira Funahashi, Michael J Ziller, Richard Adams, Nicolas Rodriguez, Nicolas Le Novère, Noriko Hiroi, Hannes Planatscher, Andreas Zell, Andreas Dräger

Research output: Contribution to journalArticlepeer-review


With the increasing availability of high dimensional time course data for metabolites, genes, and fluxes, the mathematical description of dynamical systems has become an essential aspect of research in systems biology. Models are often encoded in formats such as SBML, whose structure is very complex and difficult to evaluate due to many special cases.
Original languageEnglish
Article number55
JournalBMC Systems Biology
Publication statusPublished - 2013


  • Algorithms
  • Models, Statistical
  • Systems Biology


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