Abstract / Description of output
This paper investigates the effect of recombinant human macrophage colony-stimulating factor (CSF-1) on the interaction between mononuclear phagocytes and the metastatic murine melanoma, B16/B16. CSF-1 had no effect on the ability of primary or bone marrow-derived macrophages to kill B16 cells in vitro, nor on their activation for cytotoxicity by gamma interferon plus LPS. However, when administered in vivo, CSF-1 increased the number of monocytes and peritoneal cells in tumor-bearing animals, and led to a significant reduction in the appearance of pulmonary and extra-pulmonary metastatic lesions derived from primary B16 tumors. The results suggest a therapeutic potential for CSF-1 in the treatment of malignancy.
| Original language | English |
|---|---|
| Pages (from-to) | 69-77 |
| Number of pages | 9 |
| Journal | Lymphokine research |
| Volume | 8 |
| Issue number | 1 |
| Publication status | Published - 1989 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Body Weight
- Colony-Stimulating Factors
- Female
- Granulocyte-Macrophage Colony-Stimulating Factor
- Growth Substances
- Melanoma, Experimental
- Mice
- Mice, Inbred C57BL
- Neoplasm Metastasis
- Recombinant Proteins