The timing and degree of fetal systemic and cerebral inflammatory responses correlate with a subset of heart rate variability measures: Evidence of cholinergic anti-inflammatory pathway activation in sepsis

Lucien Daniel Durosier; Dora Siontas; Mingju Cao; Christophe L Herry; Geoff Green; Batkin, I; Patrick Burns; Gilles Fecteau; André Desrochers; Andrew J E Seely; Martin G Frasch

doi:10.1016/j.jcrc.2012.10.065

The timing and degree of fetal systemic and cerebral inflammatory responses correlate with a subset of heart rate variability measures: Evidence of cholinergic anti-inflammatory pathway activation in sepsis

Lucien Daniel Durosier, Dora Siontas, Mingju Cao, Christophe L Herry, Geoff Green, Batkin, I, Patrick Burns, Gilles Fecteau, André Desrochers, Andrew J E Seely, Martin G Frasch

Research output: Contribution to journal › Meeting abstract › peer-review

Abstract

Studies in adult animals treated with lipopolysaccharide (LPS) to model sepsis and clinicopathologic studies indicate that loss of the cholinergic anti-inflammatory pathway (CAP) inhibitory influence unleashes innate immunity, increasing proinflammatory mediators that exacerbate tissue damage, and decrease short-term heart rate variability (HRV). One proven measure of HRV is the root mean square of successive differences in R-R intervals of electrocardiogram (RMSSD), which reflects vagal modulation of HRV.

Original language	English
Pages (from-to)	e25-e25
Number of pages	1
Journal	Journal of Critical Care
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.jcrc.2012.10.065
Publication status	Published - Feb 2013
Externally published	Yes

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10.1016/j.jcrc.2012.10.065

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Durosier, L. D., Siontas, D., Cao, M., Herry, C. L., Green, G., I, B., Burns, P., Fecteau, G., Desrochers, A., Seely, A. J. E., & Frasch, M. G. (2013). The timing and degree of fetal systemic and cerebral inflammatory responses correlate with a subset of heart rate variability measures: Evidence of cholinergic anti-inflammatory pathway activation in sepsis. Journal of Critical Care, 28(1), e25-e25. https://doi.org/10.1016/j.jcrc.2012.10.065

Durosier, Lucien Daniel ; Siontas, Dora ; Cao, Mingju ; Herry, Christophe L ; Green, Geoff ; I, Batkin, ; Burns, Patrick ; Fecteau, Gilles ; Desrochers, André ; Seely, Andrew J E ; Frasch, Martin G. / The timing and degree of fetal systemic and cerebral inflammatory responses correlate with a subset of heart rate variability measures: Evidence of cholinergic anti-inflammatory pathway activation in sepsis. In: Journal of Critical Care. 2013 ; Vol. 28, No. 1. pp. e25-e25.

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title = "The timing and degree of fetal systemic and cerebral inflammatory responses correlate with a subset of heart rate variability measures: Evidence of cholinergic anti-inflammatory pathway activation in sepsis",

abstract = "Studies in adult animals treated with lipopolysaccharide (LPS) to model sepsis and clinicopathologic studies indicate that loss of the cholinergic anti-inflammatory pathway (CAP) inhibitory influence unleashes innate immunity, increasing proinflammatory mediators that exacerbate tissue damage, and decrease short-term heart rate variability (HRV). One proven measure of HRV is the root mean square of successive differences in R-R intervals of electrocardiogram (RMSSD), which reflects vagal modulation of HRV.",

author = "Durosier, {Lucien Daniel} and Dora Siontas and Mingju Cao and Herry, {Christophe L} and Geoff Green and Batkin, I and Patrick Burns and Gilles Fecteau and Andr{\'e} Desrochers and Seely, {Andrew J E} and Frasch, {Martin G}",

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doi = "10.1016/j.jcrc.2012.10.065",

language = "English",

volume = "28",

pages = "e25--e25",

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Durosier, LD, Siontas, D, Cao, M, Herry, CL, Green, G, I, B, Burns, P, Fecteau, G, Desrochers, A, Seely, AJE & Frasch, MG 2013, 'The timing and degree of fetal systemic and cerebral inflammatory responses correlate with a subset of heart rate variability measures: Evidence of cholinergic anti-inflammatory pathway activation in sepsis', Journal of Critical Care, vol. 28, no. 1, pp. e25-e25. https://doi.org/10.1016/j.jcrc.2012.10.065

The timing and degree of fetal systemic and cerebral inflammatory responses correlate with a subset of heart rate variability measures: Evidence of cholinergic anti-inflammatory pathway activation in sepsis. / Durosier, Lucien Daniel; Siontas, Dora; Cao, Mingju; Herry, Christophe L; Green, Geoff; I, Batkin,; Burns, Patrick; Fecteau, Gilles; Desrochers, André; Seely, Andrew J E; Frasch, Martin G.

In: Journal of Critical Care, Vol. 28, No. 1, 02.2013, p. e25-e25.

Research output: Contribution to journal › Meeting abstract › peer-review

TY - JOUR

T1 - The timing and degree of fetal systemic and cerebral inflammatory responses correlate with a subset of heart rate variability measures: Evidence of cholinergic anti-inflammatory pathway activation in sepsis

AU - Durosier, Lucien Daniel

AU - Siontas, Dora

AU - Cao, Mingju

AU - Herry, Christophe L

AU - Green, Geoff

AU - I, Batkin,

AU - Burns, Patrick

AU - Fecteau, Gilles

AU - Desrochers, André

AU - Seely, Andrew J E

AU - Frasch, Martin G

PY - 2013/2

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N2 - Studies in adult animals treated with lipopolysaccharide (LPS) to model sepsis and clinicopathologic studies indicate that loss of the cholinergic anti-inflammatory pathway (CAP) inhibitory influence unleashes innate immunity, increasing proinflammatory mediators that exacerbate tissue damage, and decrease short-term heart rate variability (HRV). One proven measure of HRV is the root mean square of successive differences in R-R intervals of electrocardiogram (RMSSD), which reflects vagal modulation of HRV.

AB - Studies in adult animals treated with lipopolysaccharide (LPS) to model sepsis and clinicopathologic studies indicate that loss of the cholinergic anti-inflammatory pathway (CAP) inhibitory influence unleashes innate immunity, increasing proinflammatory mediators that exacerbate tissue damage, and decrease short-term heart rate variability (HRV). One proven measure of HRV is the root mean square of successive differences in R-R intervals of electrocardiogram (RMSSD), which reflects vagal modulation of HRV.

U2 - 10.1016/j.jcrc.2012.10.065

DO - 10.1016/j.jcrc.2012.10.065

M3 - Meeting abstract

VL - 28

SP - e25-e25

JO - Journal of Critical Care

JF - Journal of Critical Care

SN - 0883-9441

IS - 1

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