The timing and degree of fetal systemic and cerebral inflammatory responses correlate with a subset of heart rate variability measures: Evidence of cholinergic anti-inflammatory pathway activation in sepsis

Lucien Daniel Durosier, Dora Siontas, Mingju Cao, Christophe L Herry, Geoff Green, Batkin, I, Patrick Burns, Gilles Fecteau, André Desrochers, Andrew J E Seely, Martin G Frasch

Research output: Contribution to journalMeeting abstractpeer-review

Abstract

Studies in adult animals treated with lipopolysaccharide (LPS) to model sepsis and clinicopathologic studies indicate that loss of the cholinergic anti-inflammatory pathway (CAP) inhibitory influence unleashes innate immunity, increasing proinflammatory mediators that exacerbate tissue damage, and decrease short-term heart rate variability (HRV). One proven measure of HRV is the root mean square of successive differences in R-R intervals of electrocardiogram (RMSSD), which reflects vagal modulation of HRV.
Original languageEnglish
Pages (from-to)e25-e25
Number of pages1
JournalJournal of Critical Care
Volume28
Issue number1
DOIs
Publication statusPublished - Feb 2013
Externally publishedYes

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