Abstract
Studies in adult animals treated with lipopolysaccharide (LPS) to model sepsis and clinicopathologic studies indicate that loss of the cholinergic anti-inflammatory pathway (CAP) inhibitory influence unleashes innate immunity, increasing proinflammatory mediators that exacerbate tissue damage, and decrease short-term heart rate variability (HRV). One proven measure of HRV is the root mean square of successive differences in R-R intervals of electrocardiogram (RMSSD), which reflects vagal modulation of HRV.
Original language | English |
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Pages (from-to) | e25-e25 |
Number of pages | 1 |
Journal | Journal of Critical Care |
Volume | 28 |
Issue number | 1 |
DOIs | |
Publication status | Published - Feb 2013 |
Externally published | Yes |