The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis

David C F Sealey, Aleksandar D Kostic, Catherine LeBel, Fiona Pryde, Lea Harrington

Research output: Contribution to journalArticlepeer-review

Abstract

The first telomerase-associated protein (Est1) was isolated in yeast due to its essential role in telomere maintenance. The human counterparts EST1A, EST1B, and EST1C perform diverse functions in nonsense-mediated mRNA decay (NMD), telomere length homeostasis, and telomere transcription. Although Est1 and EST1A/B interact with the catalytic subunit of yeast and human telomerase (Est2 and TERT, respectively), the molecular determinants of these interactions have not been elaborated fully.
Original languageEnglish
Article number45
JournalBMC Molecular Biology
Volume12
DOIs
Publication statusPublished - 2011

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